Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pleural Disorders: Types and Brief Description01:30

Pleural Disorders: Types and Brief Description

230
The pleura is a vital part of the respiratory system. It's a double-layered membrane surrounding the lungs and lining the chest cavity. The two layers of the pleura are:
230

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame journal

TROP2 immunoreactivity in pulmonary large cell neuroendocrine carcinoma.

Histopathology·2026
Same author

Glutamine fructose 6-phosphate transaminase-2 as a marker of mesothelial proliferations.

Histopathology·2026
Same author

Association of CT Features with Radiologic Patterns in Interstitial Lung Disease: Multinomial Analysis in CARE-PF.

Radiology·2026
Same author

Well-differentiated papillary mesothelial tumour: histologic, molecular and genetic features support a benign clonal neoplasm despite diffuse peritoneal involvement.

Histopathology·2025
Same author

The utility of deeper levels in evaluating transbronchial cryobiopsy specimens for interstitial lung disease.

Histopathology·2025
Same author

Pleuroparenchymal Fibroelastosis: Update on CT and Histologic Findings.

Radiology. Cardiothoracic imaging·2025
Same journal

Malignant adenomyoepithelioma of the breast: seven cases illustrating morphological diversity and diagnostic challenges.

Histopathology·2026
Same journal

A CRX-positive RB1-deficient bone tumour with a retinoblastoma-like DNA methylation profile.

Histopathology·2026
Same journal

Perivascular epithelioid cell tumours of the genitourinary tract: clinicopathological features and molecular landscape.

Histopathology·2026
Same journal

Navigating diagnostic challenges in low-grade spindle cell lesions of the breast: a retrospective review.

Histopathology·2026
Same journal

Neoplastic transformation of sporadic gastric hyperplastic polyps: a systematic review and meta-analysis of risk factors and clinicopathological features.

Histopathology·2026
See all related articles

Related Experiment Video

Updated: Jul 16, 2025

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
07:54

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Published on: December 21, 2019

6.9K

New developments in mesothelial pathology.

Andrew Churg1

  • 1Department of Pathology, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada.

Histopathology
|September 11, 2023
PubMed
Summary
This summary is machine-generated.

This review discusses mesothelioma in situ and well-differentiated papillary mesothelial tumor (WDPMT), highlighting diagnostic challenges and the role of BAP1/MTAP immunohistochemistry. New stains like HEG1 and claudin-4 aid in differentiating mesothelioma from other cancers.

Keywords:
BAP1HEG1benign mesothelial reactionclaudin-4mesothelioma in situwell-differentiated papillary mesothelial tumour

More Related Videos

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines
08:01

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Published on: April 21, 2022

1.9K
Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model
09:31

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model

Published on: October 2, 2015

9.2K

Related Experiment Videos

Last Updated: Jul 16, 2025

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
07:54

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Published on: December 21, 2019

6.9K
Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines
08:01

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Published on: April 21, 2022

1.9K
Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model
09:31

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model

Published on: October 2, 2015

9.2K

Area of Science:

  • Pathology
  • Oncology
  • Immunohistochemistry

Background:

  • Mesothelial pathology presents diagnostic challenges, particularly distinguishing in situ lesions from benign mimics and differentiating well-differentiated papillary mesothelial tumor (WDPMT) from invasive mesothelioma.
  • Loss of BAP1 and/or MTAP by immunohistochemistry defines mesothelioma in situ, but benign reactions can mimic this finding.
  • The behavior of WDPMT remains debated, with some cases resembling mesothelioma in situ.

Purpose of the Study:

  • To review current understanding and problem areas in mesothelial pathology.
  • To clarify the concept and diagnosis of mesothelioma in situ and WDPMT.
  • To introduce novel immunohistochemical markers for accurate mesothelial tumor diagnosis.

Main Methods:

  • Review of existing literature and diagnostic criteria for mesothelial lesions.
  • Analysis of immunohistochemical markers, including BAP1, MTAP, HEG1, and claudin-4.
  • Discussion of differential diagnoses between benign and malignant mesothelial proliferations.

Main Results:

  • Mesothelioma in situ is characterized by bland mesothelial cells lacking BAP1/MTAP, with benign effusions as a potential mimic.
  • WDPMT diagnosis requires careful evaluation, with BAP1 staining recommended to differentiate from mesothelioma in situ.
  • HEG1 and claudin-4 demonstrate high sensitivity and specificity for distinguishing epithelioid mesothelioma from non-small cell lung cancer.

Conclusions:

  • Mesothelioma in situ and WDPMT are associated with an increased risk of invasive mesothelioma development.
  • Immunohistochemistry, particularly BAP1, is crucial for diagnosing mesothelioma in situ and WDPMT.
  • HEG1 and claudin-4 are valuable tools for differentiating epithelioid mesothelioma from other malignancies.