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Related Experiment Video

Updated: May 22, 2025

A Multimodal Imaging Approach Based on Micro-CT and Fluorescence Molecular Tomography for Longitudinal Assessment of Bleomycin-Induced Lung Fibrosis in Mice

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Published on: April 13, 2018

Pleuroparenchymal Fibroelastosis: Update on CT and Histologic Findings.

Joel L Gamble¹, Nestor L Müller¹, Andrew Churg²

¹Department of Radiology, Vancouver General Hospital, University of British Columbia, 899 W 12th Ave, Vancouver, BC, Canada V5Z 1L5.

Radiology. Cardiothoracic Imaging

|March 13, 2025

Summary

This summary is machine-generated.

Pleuroparenchymal fibroelastosis (PPFE) is an interstitial lung disease (ILD) with distinct CT findings. This review familiarizes radiologists with PPFE

Keywords:

CT Complications Conventional Radiography Fibrosis Lung Pleura Pulmonary Thorax Transplantation

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Area of Science:

Radiology
Pulmonary Medicine
Pathology

Background:

Pleuroparenchymal fibroelastosis (PPFE) is an interstitial lung disease (ILD).
PPFE is characterized by upper lobe pleural thickening and subpleural fibrosis on CT.
Histologically, it shows visceral pleural fibrosis and subpleural fibroelastosis.

Purpose of the Study:

To summarize diagnostic criteria for PPFE.
To illustrate CT and histologic manifestations of PPFE.
To familiarize radiologists with findings suggestive of PPFE.

Main Methods:

Review of diagnostic criteria.
Illustration of CT findings.
Illustration of histologic findings.

Main Results:

PPFE shows upper lobe-predominant pleural thickening and subpleural fibrosis on CT.
Histology reveals visceral pleural fibrosis and subpleural fibroelastosis.
Many cases are associated with transplantation or other ILDs.

Conclusions:

PPFE diagnosis relies on characteristic CT and histologic findings.
Radiologists should be familiar with the spectrum of PPFE manifestations.
Understanding PPFE is crucial for accurate diagnosis and management.