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Related Concept Videos

Transgenic Organisms00:53

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Proteins perform many mechanical functions in a cell. These proteins can be classified into two general categories- proteins that generate mechanical forces and proteins that are subjected to mechanical forces. Proteins providing mechanical support to the structure of the cell, such as keratin, are subjected to mechanical force, whereas proteins involved in cell movement and transport of molecules across cell membranes, such as an ion pump, are examples of generating mechanical force. 
Mechanical Protein Function01:58

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Pharmaceutical equivalents, by definition, are drug products with the same active ingredient in the same quantities, encapsulated in identical dosage forms, and intended for the same administration routes. These pharmaceutical equivalents are deemed bioequivalent if the bioavailability of the active entity in the drug preparations is similar. Moreover, pharmaceutical equivalents demonstrating bioequivalence are also regarded as therapeutically equivalent. This means that when used as directed,...

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Tailoring biomaterials for biomimetic organs-on-chips.

Lingyu Sun1, Feika Bian1, Dongyu Xu1

  • 1Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China. yjzhao@seu.edu.cn.

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Biomaterials are crucial for developing advanced organs-on-chips, microfluidic devices mimicking human organ functions. This review highlights their role in creating better models for drug testing and understanding diseases.

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Microfluidics

Background:

  • Organs-on-chips are microfluidic devices that replicate organ functions.
  • They offer advanced cell culture mimicking in vivo environments.
  • Biomaterials are critical for organ-on-chip microstructure and function.

Purpose of the Study:

  • To provide an overview of biomaterials used in organs-on-chips.
  • To discuss biomaterial functions, fabrication, and applications.
  • To highlight the potential of organs-on-chips as alternatives to animal testing.

Main Methods:

  • Review of current literature on biomaterials for organs-on-chips.
  • Analysis of biomaterial components, structures, and fabrication techniques.
  • Examination of biomaterial functions and applications in organ-on-chip systems.

Main Results:

  • Biomaterials significantly influence the performance of organs-on-chips.
  • Various biomaterials are employed, affecting cell behavior and device functionality.
  • Biomaterial-based organs-on-chips show promise as alternatives to animal models.

Conclusions:

  • Biomaterials are essential for advancing organ-on-chip technology.
  • Further research into biomaterials will enhance organ-on-chip capabilities.
  • These advanced models have significant implications for pharmaceutical, chemical, and environmental testing.