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Updated: Jul 16, 2025
Facile Preparation and Photoactivation of Prodrug-Dye Nanoassemblies
Published on: February 17, 2023
A diketopyrrolopyrrole-based small molecule with an extended conjugated skeleton and J-aggregation behavior for 808
Jiawei Liu1, Xinmin Zhang1, Mingxuan Fu1
1State Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, Nanjing 210023, China. iamqwang@njupt.edu.cn.
Abstract:
The development of phototheranostic agents, specifically those based on organic small molecules (OSMs) with long wavelength excitation/emission, is an attractive but challenging project. In this contribution, we designed and synthesized a novel conjugate small molecule with a linear structure, named DPP-OPIC. Water-soluble nanoparticle DPP-OPIC NPs were fabricated. They exhibited strong absorption in the region of 600-1000 nm, which was due to the extended conjugate length of the molecular skeleton and J-aggregation behavior. Under 808 nm laser excitation, DPP-OPIC NPs were capable of producing outstanding near-infrared-II (NIR-II, 900-1700 nm) fluorescence. The photoluminescence quantum yield was determined as 0.58%, which enabled high-resolution in vivo tumor imaging. Additionally, a notable photothermal effect with a high photothermal conversion efficiency (41.5%) was achieved by the irradiation of DPP-OPIC NPs. Hence, DPP-OPIC NPs can be used as superior phototheranostic agents, providing valuable contributions to NIR-II fluorescence imaging and photothermal therapy.
