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Related Experiment Video

Updated: Jul 16, 2025

Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion
08:54

Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion

Published on: April 27, 2015

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Machine perfusion in liver transplantation.

Samuel J Tingle1, Joseph J Dobbins2, Emily R Thompson3

  • 1NIHR Blood and Transplant Research Unit, Newcastle University and Cambridge University, Newcastle upon Tyne, UK.

The Cochrane Database of Systematic Reviews
|September 12, 2023
PubMed
Summary
This summary is machine-generated.

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Hypothermic oxygenated machine perfusion (HOPE) improves liver transplant outcomes, including graft survival and reducing adverse events, compared to static cold storage. Normothermic machine perfusion (NMP) shows no similar benefits but may increase organ utilization.

Area of Science:

  • Organ transplantation
  • Surgical innovation
  • Medical device technology

Background:

  • Liver transplantation is a life-saving procedure for end-stage liver disease, advanced cancers, and acute liver failure.
  • Increasing demand necessitates the use of suboptimal donated livers, driving the need for improved preservation techniques.
  • Machine perfusion technologies aim to mitigate ischemia-reperfusion injury and enhance organ quality compared to static cold storage (SCS).

Approach:

  • Systematic review and meta-analysis of randomized clinical trials comparing machine perfusion methods (HOPE, NMP) against SCS.
  • Primary outcomes included participant survival, quality of life, and serious adverse events.
  • Secondary outcomes assessed graft survival, biliary complications, graft function, and organ utilization.

Key Points:

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Related Experiment Videos

Last Updated: Jul 16, 2025

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Published on: April 27, 2015

17.0K
Normothermic Ex Vivo Liver Machine Perfusion in Mouse
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Ex Situ Normothermic Machine Perfusion of Donor Livers
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  • Hypothermic oxygenated machine perfusion (HOPE) significantly improved graft survival and reduced serious adverse events in extended criteria liver transplants.
  • HOPE demonstrated a reduction in clinically relevant ischemic biliary complications in recipients of livers from donors after circulatory death (DCD).
  • Normothermic machine perfusion (NMP) did not show improvements in survival or adverse events but was associated with higher organ utilization rates.

Conclusions:

  • HOPE offers superior clinically relevant outcomes compared to SCS for liver transplantation, particularly for DCD and DBD liver grafts.
  • While NMP did not demonstrate equivalent clinical benefits, its potential to increase graft utilization warrants further investigation.
  • Ongoing studies and head-to-head trials are crucial to further elucidate the comparative efficacy and optimal application of machine perfusion technologies.