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Updated: Jul 16, 2025

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
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Prader-Willi syndrome: an update

Jessica Duis1

  • 1Section of Genetics & Inherited Metabolic Disease, Department of Pediatrics, University of Colorado, Aurora, Colorado, USA.

Current Opinion in Pulmonary Medicine
|September 13, 2023
PubMed

Insights

Sleep disorders in Prader-Willi syndrome (PWS) are common, affecting breathing and neurological function. Early recognition and management of excessive daytime sleepiness and other sleep issues are crucial for daily functioning.

Area of Science:

  • Neurology
  • Sleep Medicine
  • Genetics

Background:

  • Prader-Willi syndrome (PWS) is associated with a wide range of sleep disorders.
  • These disorders significantly impact daily functioning, including attention, behavior, and mood.

Purpose of the Study:

  • To review the spectrum of sleep disorders in PWS.
  • To discuss current knowledge regarding the management of these sleep conditions.

Main Methods:

  • Literature review of studies characterizing sleep disorders in PWS.
  • Synthesis of information on treatment strategies for PWS-related sleep issues.

Main Results:

  • Sleep disorders in PWS encompass respiratory and neurological conditions.
  • Excessive daytime sleepiness and a modified narcolepsy phenotype are recognized.
  • Sleep disturbances contribute to inattention, irritability, and behavioral outbursts.

Conclusions:

  • Sleep disorders are a critical consideration in individuals with PWS.
  • Effective management strategies are available and important for improving quality of life.
Abstract

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