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Updated: Jul 16, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Non-noble metal-catalyzed cross-dehydrogenation coupling (CDC) involving ether α-C(sp3)-H to construct C-C bonds
1Department of Pharmacy, Shi zhen College of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou 550200, P. R. China.
Abstract:
Ether derivatives are widespread as essential building blocks in various drugs, natural products, agrochemicals, and materials. Modern economy requires developing green strategies with improved efficiency and reduction of waste. Due to its atom and step-economy, the cross-dehydrogenative coupling (CDC) reaction has become a major strategy for ether functionalization. This review covers C-H/C-H cross-coupling reactions of ether derivatives with various C-H bond substrates via non-noble metal catalysts (Fe, Cu, Co, Mn, Ni, Zn, Y, Sc, In, Ag). We discuss advances achieved in these CDC reactions and hope to attract interest in developing novel methodologies in this field of organic chemistry.
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