Related Experiment Video

Updated: Jul 16, 2025

A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis
06:41

A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis

Published on: March 9, 2015

9.0K

Commonly Associated Disorders with Complete Scalp Alopecia in Early Childhood: A Review

Michaela Rose Rand1, Katerina Yale1, Brian Satoshi Kato2

  • 1Department of Dermatology, University of California, Irvine, California 92697, USA.

International Journal of Trichology
|September 13, 2023
PubMed

Insights

This review identifies six common genetic conditions causing complete scalp hair loss in children. Early recognition of these genetic alopecia causes can improve diagnosis and prognosis for affected children.

Area of Science:

  • Pediatric Dermatology
  • Medical Genetics
  • Trichology

Background:

  • Complete scalp hair loss in children, or alopecia, causes significant distress.
  • While infections and trauma are common causes, genetic factors play a crucial role in pediatric alopecia.
  • Identifying genetic predispositions is key for accurate diagnosis and management.

Purpose of the Study:

  • To identify and review common genetic conditions associated with complete scalp alopecia in infants and children.
  • To synthesize current literature on genetic alopecia in pediatric populations.
  • To enhance awareness among clinicians regarding genetic causes of pediatric hair loss.

Main Methods:

  • Comprehensive literature review of the PubMed Database from 1962 to 2019.
  • Inclusion of studies with at least five reported cases of genetic alopecia in humans.
  • Focus on clinical trials, retrospective studies, and case reports in English.

Main Results:

  • Six genetic conditions were identified as common causes of complete scalp hair loss in children.
  • These include alopecia totalis/Alopecia universalis (AU), atrichia with papular lesions, AU congenita, hereditary Vitamin D-resistant rickets type IIA, alopecia with mental retardation, and pure hair and nail ectodermal dysplasia.
  • The review highlights the diverse genetic landscape underlying pediatric alopecia.

Conclusions:

  • A variety of genetic and environmental factors can cause total scalp hair loss in children.
  • Increased clinical awareness of these genetic conditions is vital for timely diagnosis.
  • Improved diagnostic capabilities can lead to better prognoses for children with genetic alopecia.

Keywords:
Alopeciadermatologygenetichair losspediatric

More Related Videos

Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE06:04

Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE

Published on: August 16, 2024

885
A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)07:01

A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)

Published on: February 7, 2025

472

Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
3.9K
Autism Spectrum Disorder01:19

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
121
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
90
Adrenal Gland Disorders01:27

Adrenal Gland Disorders

Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
1.6K
Conduct Disorder01:28

Conduct Disorder

Conduct disorder is a complex mental health diagnosis characterized by a repetitive and persistent pattern of behavior that violates societal norms, the rights of others, or age-appropriate rules. The diagnostic criteria for conduct disorder require the presence of at least three problematic behaviors within the past 12 months, with at least one occurring in the past six months. These behaviors are grouped into four categories: aggression toward people and animals; destruction of property;...
52
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
107