Ferulic Acid Use for Skin Applications: A Systematic Review

Area of Science:

• Dermatology
• Cosmetic Science

Background:

• Ferulic acid (FA) is increasingly utilized in skincare for its antioxidant and anti-inflammatory properties.
• Its clinical efficacy and optimal application in human subjects necessitate thorough evaluation.

Purpose of the Study:

• To conduct a comprehensive review of existing literature on the topical application of ferulic acid in skincare.
• To evaluate the effectiveness of ferulic acid in various dermatological conditions and cosmetic applications.

Main Methods:

• A systematic literature search was performed using PubMed and Cochrane databases.
• Inclusion criteria focused on human studies investigating ferulic acid's skin effects, published between January 1983 and June 2023.

Main Results:

• Eighteen human studies indicated ferulic acid's efficacy in improving skin erythema, pigmentation, hydration, elasticity, and texture.
• Ferulic acid demonstrated effectiveness both as a standalone ingredient and in combination therapies, across diverse subject populations.

Conclusions:

• Current evidence supports ferulic acid formulations in mitigating skin erythema, hyperpigmentation, and aging signs in adults.
• Limitations include small sample sizes, limited population diversity, and varied formulation compositions, highlighting the need for more rigorous studies.
• Further research is essential to elucidate ferulic acid's mechanisms of action and optimize its use in treating skin conditions.