Related Experiment Video
Updated: Sep 21, 2026

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
Published on: March 24, 2023
OX40/OX40L Costimulatory Pathway: A Potential Therapeutic Target for Allergic Contact Dermatitis?
Walter Liszewski1, Naiem Issa2
1Dr. Liszewski is with the Department of Dermatology and the Department of Cancer Epidemiology, Northwestern University, Chicago, Illinois.
Abstract:
OX40 and OX40L inhibitors represent the next generation of therapies to treat atopic dermatitis. However, because to their unique mechanism, they have tremendous potential to treat allergic contact dermatitis. Although the cornerstone of allergic contact dermatitis management is allergen avoidance, it is not possible in all cases. In this article, we outline the immunology of these drugs and how they could be leveraged to treat refractory allergic contact dermatitis.

