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Relationship between catheter related cerebrospinal fluid infections and systemic immune-inflammation index
Sebnem Nergiz1, Pinar Aydin Ozturk2
1Department of Dietetics and Nutrition, Dicle University, Ataturk Faculty of Health Sciences, Diyarbakir, Turkey.
Insights
The systemic immune inflammation index (SII) was elevated in pediatric patients with ventriculoperitoneal (V-P) shunt infections, particularly those caused by non-coagulase-negative staphylococci. This finding may aid in early infection detection.
Area of Science:
- Pediatric Infectious Diseases
- Biomarkers in Infection
- Neurocritical Care
Background:
- Catheter-related infections, specifically ventriculoperitoneal (V-P) shunt infections, pose significant risks in pediatric patients.
- Early diagnosis and treatment are crucial for reducing morbidity and mortality associated with these infections.
Purpose of the Study:
- To investigate the association between the systemic immune inflammation index (SII) and catheter-related infections in pediatric patients.
- To explore the impact of SII on prognosis and identify potential predictive factors for V-P shunt infections.
Main Methods:
- Retrospective analysis of 56 pediatric patients with V-P shunt infections between January 2017 and October 2019.
- Analysis of clinical findings, cerebrospinal fluid (CSF) parameters (protein, glucose, sodium, leukocytes), and hematological/biochemical markers.
- Comparison of SII levels between different causative agents, including coagulase-negative staphylococci.
Main Results:
- The systemic immune inflammation index (SII) was significantly increased in patients with V-P shunt infections (p=0.002).
- A significantly lower CSF/blood glucose ratio was observed (p=0.046).
- Elevated SII was particularly noted in infections not caused by coagulase-negative staphylococci.
Conclusions:
- The systemic immune inflammation index (SII) may serve as a valuable biomarker for detecting V-P shunt infections in pediatric patients.
- Further research is warranted to explore the predictive value of SII and other factors in guiding empirical antibiotic therapy.
Background:
This study investigated the relationship between the systemic immune inflammation index (SII) and catheter-related infections and their effects on prognosis in pediatric patients.
Methods:
A total of 56 pediatric patients diagnosed with ventriculoperitoneal (V-P) shunt infection between January 2017 and October 2019 were included. V-P shunt infection diagnosis was made based on clinical findings. All cerebrospinal fluid (CSF) samples were subjected to direct microscopic examination and culture. Protein, glucose, and sodium levels in CSF, CSF leukocytes, and hematological and biochemical parameters were measured.
Results:
Fifty-six patients with growth in CSF culture were included in this study. 55.4% of the cases were female and 44.6% male. V-P shunt was detected in 82.1% of the cases and external ventricular drainage (EVD) catheter-related infection in 17.9%. The CSF/blood glucose ratio was significantly lower (p = 0.046), and SII was significantly increased (p = 0.002) in non-coagulase-negative staphylococci.
Conclusions:
Early and appropriate antibiotic therapy reduces morbidity and mortality in catheter-related infections. However, it is important to start empirical antibiotherapy until culture results are expected. Therefore, further research on the estimation of possible factors is needed.
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