Biomolecule-Driven Two-Factor Authentication Strategy for Access Control of Molecular Devices

Area of Science:

• Biomolecular Engineering
• Information Security
• DNA Nanotechnology

Background:

• Advancements in DNA nanotechnology are crucial for developing next-generation molecular security devices.
• Existing molecular security faces challenges in robust access control against increasing computing power and quantum computing threats.

Purpose of the Study:

• To develop a secure and reliable biomolecule-driven two-factor authentication strategy for molecular device access control.
• To create a one-time password (OTP) system leveraging DNA sequence programmability and enzyme specificity.

Main Methods:

• Utilized the specificity and nicking properties of nicking enzymes.
• Applied programmable DNA sequence design for OTP generation.
• Developed a role-based molecular access control device with a command library (Ca, Cb, Ca and Cb) for three distinct user roles.

Main Results:

• Successfully demonstrated a two-factor authentication strategy for molecular devices.
• Implemented role-based access control, enabling authorized access for roles A, B, and C based on specific commands.
• Ensured users require both correct factors and prior role authorization for accessing secret information.

Conclusions:

• The developed strategy provides a highly robust method for molecular device access control.
• This research lays the foundation for next-generation information security solutions utilizing DNA nanotechnology.