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Lnc-ing epigenetic mechanisms with autophagy and cancer drug resistance

Sandhik Nandi1, Atanu Mondal1, Aritra Ghosh2

  • 1Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, Kolkata, India; Homi Bhabha National Institute, Mumbai, India.

Advances in Cancer Research
|September 13, 2023
PubMed

Insights

Long noncoding RNAs (lncRNAs) regulate cell death pathways, including autophagy. Targeting lncRNAs involved in autophagy may overcome cancer drug resistance and improve targeted cancer therapy.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Long noncoding RNAs (lncRNAs) are key regulators of physiological processes and implicated in diseases like cancer.
  • Therapeutic resistance remains a significant challenge in cancer treatment.
  • lncRNAs play a role in cancer drug resistance and regulate cell death pathways.

Purpose of the Study:

  • To discuss the role of lncRNAs in autophagy-mediated cancer drug resistance.
  • To explore the implications of lncRNAs in targeted cancer therapy.

Main Methods:

  • Literature review of studies on lncRNAs, autophagy, and cancer drug resistance.
  • Analysis of the interplay between lncRNAs and autophagosomal axis in cancer cells.

Main Results:

  • lncRNAs regulate autophagy, a process with dual roles in cell survival and death.
  • Autophagy can influence both chemosensitization and chemoresistance in cancer.
  • Emerging evidence highlights lncRNAs' role in modulating autophagy.

Conclusions:

  • lncRNAs are critical regulators of autophagy-mediated cancer drug resistance.
  • Targeting the lncRNA-autophagy axis presents a promising strategy for overcoming chemoresistance.
  • lncRNAs hold potential for enhancing targeted cancer therapy.
Keywords:
ATGAutophagyCancer therapyChemoresistanceLC3LncRNA

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