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Updated: Jul 16, 2025

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
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Variant allele frequency: a decision-making tool in precision oncology?

Luca Boscolo Bielo1, Dario Trapani1, Matteo Repetto2

  • 1Division of New Drugs and Early Drug Development for Innovative Therapies, European Institute of Oncology, IRCCS, Milan, Italy; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.

Trends in Cancer
|September 13, 2023
PubMed
Summary

Variant allele frequency (VAF) shows promise as a predictive biomarker in precision oncology for selecting targeted therapies. Further validation is needed to standardize its clinical use.

Keywords:
biomarker qualificationprecision oncologypredictive biomarkertargeted therapyvariant allele frequency

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