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An Overview on Anti-COVID-19 Drug Achievements and Challenges Ahead

Mehdi Valipour1, Hamid Irannejad2, Hossein Keyvani3

  • 1Razi Drug Research Center, Iran University of Medical Sciences, Tehran 1134845764, Iran.

ACS Pharmacology & Translational Science
|September 14, 2023
PubMed

Insights

Future coronavirus threats necessitate better drug development. Despite efforts, effective treatments for COVID-19 remain elusive, highlighting the urgent need for preparedness against emerging infectious diseases.

Area of Science:

  • Virology
  • Infectious Diseases
  • Public Health

Background:

  • Recurrent coronavirus outbreaks (SARS-CoV-1, MERS-CoV, SARS-CoV-2) signal escalating future risks.
  • Emerging strains may combine high transmissibility with severe mortality rates, posing significant global health threats.

Purpose of the Study:

  • To review drug development achievements and challenges against SARS-CoV-2.
  • To provide insights from pharmacology, pharmacotherapy, and medicinal chemistry.
  • To emphasize the need for enhanced preparedness against future coronavirus pandemics.

Main Methods:

  • Literature review synthesizing pharmacological, pharmacotherapeutic, and medicinal chemistry perspectives.
  • Analysis of drug discovery efforts and clinical outcomes for COVID-19 treatments.

Main Results:

  • Current drug discovery and pharmacotherapy for COVID-19 have not yet yielded desired outcomes.
  • Significant challenges persist in developing effective treatments against SARS-CoV-2.

Conclusions:

  • Despite extensive research, successful drug interventions for COVID-19 are lacking.
  • Increased preparedness and continued research are crucial for future coronavirus threats.
  • Authorities must prioritize readiness for potential future pandemics.

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