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Case report: Allogeneic stem cell transplantation for type B insulin resistance
Thomas Ebert1, Gerhard Behre2,3, Lorenz Weidhase4
1Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.
Frontiers in Medicine
|September 14, 2023
Summary
Type B insulin resistance (TBIR), a severe condition, can be effectively treated with allogeneic peripheral blood stem cell transplantation (PBSCT). This approach offers a stable remission option when other therapies fail.
Area of Science:
- Endocrinology
- Immunology
- Hematology
Background:
- Type B insulin resistance (TBIR) is a rare autoimmune disorder characterized by autoantibodies against the insulin receptor.
- TBIR presents with severe insulin resistance and high mortality if untreated.
- Conventional immunosuppressive therapies for TBIR have variable efficacy and potential complications.
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