Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vaccinations01:51

Vaccinations

44.7K
Overview
44.7K
Pneumonia V: Nursing management and Prevention01:30

Pneumonia V: Nursing management and Prevention

2.2K
Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
2.2K
Cystic Fibrosis: Management01:24

Cystic Fibrosis: Management

191
Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic...
191
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

2.7K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
2.7K
Multiple Allele Traits01:49

Multiple Allele Traits

34.3K
The Concept of Multiple Allelism
34.3K
Cancer Vaccines01:30

Cancer Vaccines

399
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
399

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Implementation and Evaluation of an Alternative Electronic Health Record Tool for Ordering Blood Products in Pediatric Oncology and Stem Cell Transplantation: Mixed Methods Analysis.

JMIR medical informatics·2026
Same author

Leveraging clinical epidemiology concepts to strengthen machine learning fairness evaluations.

Journal of the American Medical Informatics Association : JAMIA·2026
Same author

Identifying Hemophagocytic Lymphohistiocytosis and Describing Outcomes Using Computable Phenotypes: Retrospective Cohort Study.

JMIR cancer·2026
Same author

Corrigendum: Clinical Implementation of Artificial Intelligence Scribes in Health Care: A Systematic Review.

Applied clinical informatics·2026
Same author

Integrating Symptom Screening in Pediatrics Into the Epic Electronic Health Record: Development and Acceptability for Pediatric Cancer Patients.

JCO clinical cancer informatics·2026
Same author

Creation of Blinatumomab Administration Standards: A Single Institution's Experience.

Pediatric blood & cancer·2026

Related Experiment Video

Updated: Jul 16, 2025

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
07:24

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

1.8K

Increasing COVID-19 Vaccination Rates for Children With Sickle Cell Disease.

Adam P Yan1, Natasha M Archer1, Dianne Arnold2

  • 1Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.

Pediatrics
|September 14, 2023
PubMed
Summary

COVID-19 vaccination rates for children with sickle cell disease (SCD) increased through targeted interventions. Addressing misinformation and improving access are key to boosting vaccine uptake in this vulnerable group.

More Related Videos

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

19.5K
Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

9.9K

Related Experiment Videos

Last Updated: Jul 16, 2025

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
07:24

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

1.8K
Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

19.5K
Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

9.9K

Area of Science:

  • Pediatric Health
  • Infectious Disease Prevention
  • Public Health Interventions

Background:

  • Children with sickle cell disease (SCD) are a priority group for COVID-19 vaccination due to increased health risks.
  • A quality improvement project aimed to increase the proportion of children with SCD receiving at least two COVID-19 vaccine doses to over 70% by June 2022.

Purpose of the Study:

  • To implement and evaluate strategies for increasing COVID-19 vaccination rates among children with sickle cell disease.
  • To assess the effectiveness of interventions focused on patient education, provider awareness, and vaccine accessibility.

Main Methods:

  • Utilized the Model for Improvement framework with three plan-do-study-act cycles.
  • Biweekly assessment of COVID-19 vaccination rates in children with SCD.
  • Employed interrupted time series analysis to model implementation rates and statistical process control charts for tracking changes.

Main Results:

  • Overall vaccination rates for children with SCD increased from 33% to 64% during the intervention period (February-June 2022).
  • Mean vaccination rate per 2-week period rose significantly, with 10 patients booking vaccines after outreach calls and 40% viewing an educational video.
  • Missed clinic appointments remained stable, indicating interventions did not negatively impact routine care access.

Conclusions:

  • Targeted interventions addressing misinformation and improving vaccine access can enhance COVID-19 vaccination rates in children with SCD.
  • Despite improvements, a substantial proportion of children with SCD remain unvaccinated, necessitating further interventions.
  • The project demonstrated a higher-than-predicted vaccination rate for SCD patients compared to the general population.