Related Experiment Video
Updated: Jun 29, 2026
07:22
Standardized Method for Measuring Collection Efficiency from Wipe-sampling of Trace Explosives
Published on: April 10, 2017
Creation of Blinatumomab Administration Standards: A Single Institution's Experience
Sue Zupanec1, Lisa Honeyford1, Allison Starr1
1Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Canada.
Pediatric Blood & Cancer
|January 22, 2026
Summary
Standardized blinatumomab administration protocols improved safety and efficiency in pediatric B-acute lymphoblastic leukemia (B-ALL) care. This quality improvement initiative reduced antibiotic use and practice variability, enhancing patient experience.
Area of Science:
- Pediatric Oncology
- Hematology
- Quality Improvement Science
Background:
- Blinatumomab is a vital treatment for pediatric B-acute lymphoblastic leukemia (B-ALL).
- Its administration presents operational challenges, including continuous infusion and unique toxicities.
- Standardized protocols are needed to optimize safety, efficiency, and patient experience.
Purpose of the Study:
- To develop, implement, and evaluate a standardized institutional protocol for blinatumomab administration.
- To address operational challenges and unique toxicities associated with blinatumomab therapy.
- To optimize safety, efficiency, and patient experience during blinatumomab treatment.
Main Methods:
- A multidisciplinary Blinatumomab Working Group developed harmonized standards across five domains: caregiver education, fever management, nursing assessments, infusion interruption management, and use of 7-day infusion bags.
- A quality improvement initiative was conducted at The Hospital for Sick Children, Toronto, Canada.
- Data from 53 patients receiving blinatumomab between July 2024 and August 2025 were analyzed.
Main Results:
- 100% of eligible caregivers completed standardized education.
- Empiric antibiotic use during blinatumomab initiation decreased from 68% to 22% without adverse events.
- Nursing assessment completion rates were high (95% inpatients, 81% outpatients), and infusion interruptions were managed safely.
Conclusions:
- Multidisciplinary, standardized blinatumomab administration protocols are feasible and safe.
- These protocols improved antibiotic stewardship, empowered nursing-led care, and reduced practice variability.
- This framework can inform best practices for blinatumomab delivery in pediatric oncology centers.
More Related Videos
Related Concept Videos
01:23Methods of Documentation V: CBE
Charting by Exception, or CBE, is a method of documentation used in healthcare, particularly in nursing, that focuses on documenting only significant or abnormal findings rather than recording every detail. This approach aims to streamline the documentation process, improve efficiency, and ensure that healthcare providers can quickly identify deviations from normalcy in patient assessments.
In CBE, healthcare professionals establish predefined standards of practice that define what constitutes...
In CBE, healthcare professionals establish predefined standards of practice that define what constitutes...
01:05Quality Control
Quality control is one of the three cyclical quality assurance activities that help keep a system under statistical control. Typical quality control activities include creating quality control charts, conducting proficiency testing, and documenting and archiving results.
Quality control helps track data, visualize trends, and identify variations, making it easier to detect deviations that may affect the accuracy of an analysis. One way to do this is by generating a quality control chart, which...
Quality control helps track data, visualize trends, and identify variations, making it easier to detect deviations that may affect the accuracy of an analysis. One way to do this is by generating a quality control chart, which...
01:03Drug Control Governance: Regulatory Bodies and Their Impact
Drug control governance involves the oversight and regulation of pharmaceuticals to ensure their safety and efficacy while preventing illegal drug use and trafficking. Regulatory bodies, including the US Food and Drug Administration (FDA) and the European Union's European Medicines Agency (EMA), play a central role in this process. These agencies evaluate the safety and efficacy of drugs before they can be marketed. They fund clinical trials and assess the benefits and risks associated with a...
01:24Design Example: Aggregate Gradation
The right type and quality of aggregates are crucial for concrete as they significantly influence its properties, mix proportions, and cost-effectiveness. If different sources are available for sand, the commonly used fine aggregate in concrete, the selection of sand is primarily based on its gradation.
The grading, or particle-size distribution, of sand is determined using sieve analysis, with standard sizes ranging from 150 μm to 10 mm (ASTM No. 100 sieve to 3⁄8 in. sieve). Sand is sampled...
The grading, or particle-size distribution, of sand is determined using sieve analysis, with standard sizes ranging from 150 μm to 10 mm (ASTM No. 100 sieve to 3⁄8 in. sieve). Sand is sampled...
01:26Good Manufacturing Practices
Good Manufacturing Practices (GMP) constitute a foundational set of guidelines that ensure the production of safe, consistent, and high-quality products, particularly in industries such as pharmaceuticals, biotechnology, and food processing. These protocols encompass all aspects of production, from the sourcing of raw materials to the final distribution of the finished product.A core pillar of GMP is stringent hygiene and sanitation across all production environments. This includes routine...
01:30Hazard Analysis and Critical Control Points (HACCP)
Hazard Analysis and Critical Control Points (HACCP) is a science-based, preventive system used globally to ensure food safety by identifying, evaluating, and controlling biological, chemical, and physical hazards throughout food production. Originally developed by NASA and the Pillsbury Company for astronaut food, HACCP is now a core component of the Codex Alimentarius.HACCP operates on prerequisite programs—such as Good Manufacturing Practices (GMPs), sanitation procedures, and supplier...