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Prospects and challenges of CRISPR/Cas9 gene-editing technology in cancer research

Li Ning1,2, Jiahui Xi1,2, Yin Zi1,2

  • 1Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, School of Biotechnology and Health Science, Wuyi University, Jiangmen, China.

Clinical Genetics
|September 14, 2023
PubMed

Insights

Clustered regularly interspaced palindromic repeat (CRISPR)/Cas9 gene editing advances cancer research by enabling the study of gene mutations. This technology holds potential for developing novel cancer therapies and disease models.

Area of Science:

  • Oncology
  • Genetics
  • Biotechnology

Background:

  • Cancer arises from gene mutations and expression dysregulation.
  • Gene editing offers a powerful tool to investigate cancer-related genes.

Purpose of the Study:

  • To review the mechanisms and advancements of CRISPR/Cas9 gene-editing technology.
  • To explore CRISPR/Cas9 applications in cancer research, including disease models, gene therapy, and immunotherapy.

Main Methods:

  • Review of recent literature on CRISPR/Cas9 technology.
  • Analysis of CRISPR/Cas9 applications in cancer research.

Main Results:

  • CRISPR/Cas9 technology allows precise editing of cancer-related genes.
  • Potential applications include creating human tumor models and advancing gene and immunotherapies.

Conclusions:

  • CRISPR/Cas9 is a transformative technology for understanding cancer mechanisms.
  • It offers promising avenues for developing innovative cancer treatments and diagnostics.
Keywords:
CRISPR/Cas9cancer; gene-editinggene therapyimmunotherapy

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