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Updated: Jul 16, 2025

Growing Protein Crystals with Distinct Dimensions Using Automated Crystallization Coupled with In Situ Dynamic Light Scattering
Published on: August 14, 2018
Rapid single crystal growth via guest displacement from host-guest complexes
Mikayla L Horvath1, Caylee E Jumbelic1, Rosemarie A Burynski1
1Department of Chemistry, Bucknell University, Lewisburg, PA 17837, USA. hasan.arslan@bucknell.edu.
Abstract:
The preparation of single crystals of sparingly soluble polycyclic aromatic compounds in MeCN is facilitated by solubilizing ionic host-guest complexation under otherwise poor solvent conditions. The guest is then crystallized within minutes through controlled guest displacement from the host via competitor equilibria, or over days through direct crystallization of the host-guest complex itself.
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