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Malnutrition in heart failure with preserved ejection fraction
Omar Zainul1, Danny Perry2, Michael Pan3
1Weill Cornell Medical College, New York, New York, USA.
Journal of the American Geriatrics Society
|September 14, 2023
Summary
Malnutrition affects 42% of adults with heart failure with preserved ejection fraction (HFpEF). This condition independently increases the risk of hospitalization and death within six months.
Area of Science:
- Geriatric Medicine
- Cardiology
- Nutritional Science
Background:
- Malnutrition is a potential geriatric concern in heart failure with preserved ejection fraction (HFpEF).
- Limited data exists on malnutrition prevalence and outcomes in HFpEF patients.
Purpose of the Study:
- To investigate the association between malnutrition and short-term clinical outcomes in ambulatory HFpEF patients.
- To determine if malnutrition predicts morbidity and mortality in this population.
Main Methods:
- A cohort of 231 ambulatory HFpEF patients was analyzed.
- Malnutrition was assessed using the Mini-Nutritional Assessment Short Form (MNA-SF) score ≤11.
- A 6-month composite endpoint of all-cause mortality and hospitalization was evaluated using Cox proportional-hazard models.
Main Results:
- The prevalence of malnutrition was 42% (97/231 patients).
- Malnutrition was not significantly correlated with body mass index.
- Malnutrition independently predicted a composite outcome of all-cause mortality and hospitalization within 6 months (HR 1.94, p=0.01).
Conclusions:
- Despite high obesity rates, a significant proportion of HFpEF patients are malnourished.
- Malnutrition is an independent predictor of adverse 6-month outcomes in ambulatory HFpEF.
- Further research is needed to develop interventions targeting malnutrition in HFpEF.
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