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Cutaneous Atypical Fibroxanthoma With Osteoclast-Like Giant Cell: A Rare but Diagnostic Pitfall
Nada Shaker1, Robert Phelps2, George Niedt2
1Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH.
The American Journal of Dermatopathology
|September 14, 2023
Summary
A rare skin tumor, atypical fibroxanthoma (AFX) with osteoclast-like giant cells, was successfully treated in a patient. This rare neoplasm, despite concerning features, typically has a good prognosis.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Atypical fibroxanthoma (AFX) is a rare dermal neoplasm without a defined differentiation lineage.
- AFX with osteoclast-like giant cells is exceptionally rare, with fewer than 20 reported cases.
- Distinguishing this rare variant from other giant cell-containing skin lesions is critical.
