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Published on: February 17, 2017
Biological properties of (1-4)-thio disaccharides
Anna Czubatka-Bieńkowska1, Joanna Sarnik2, Tomasz Poplawski1
1Department of Pharmaceutical Microbiology and Biochemistry, Medical University, 90-136, Lodz, Poland.
Abstract:
Thio sugars are carbohydrate derivatives in which one or more oxygen atoms have been replaced with sulfur. Thio sugars are effective inhibitors of glycosylases, have considerable therapeutic potential, and are used as drugs in the treatment of diabetes and infectious diseases. The development of this branch of carbohydrate chemistry would not be possible without the development of novel methods for its synthesis and the analysis of their biochemical properties. In this Review Article, we summarize our findings on the biological properties of a collection of thio sugars and their derivatives synthesized by the Witczak and Bielski team using their original methods based on the Michael addition of sugar thiols to levoglucosenone.
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