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miRNome expression analysis in canine diffuse large B-cell lymphoma.

Nelly O Elshafie1, Michael Gribskov2, Nathanael I Lichti3

  • 1Department of Comparative Pathobiology, Purdue University, West Lafayette, IN, United States.

Frontiers in Oncology
|September 15, 2023
PubMed
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This study identified 35 microRNAs (miRNAs) with altered expression in canine diffuse large B-cell lymphoma (DLBCL). These miRNA signatures show promise as diagnostic biomarkers for early detection and monitoring of this common canine cancer.

Area of Science:

  • Veterinary Oncology
  • Molecular Biology
  • Cancer Biomarkers

Background:

  • Diffuse large B-cell lymphoma (DLBCL) is a prevalent canine cancer with significant translational relevance to human disease.
  • Early diagnosis and monitoring of DLBCL are critical for improving remission rates.
  • MicroRNAs (miRNAs) are key regulators of gene expression and stable biomarkers for disease diagnosis and prognosis.

Purpose of the Study:

  • To investigate the expression profiles of miRNAs in canine DLBCL.
  • To identify potential miRNA biomarkers for early diagnosis and monitoring of DLBCL.
  • To explore the molecular pathways targeted by differentially expressed miRNAs in canine DLBCL.

Main Methods:

  • Small RNA sequencing was performed on lymph node tissue samples from dogs with DLBCL and healthy controls.
Keywords:
cancer biomarkerscanine DLBCLdiffuse large B-cell lymphomamiRNAsmiRNomemulticentricsRNA sequencing

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  • Differentially expressed miRNAs (DEMs) were identified using bioinformatic analysis.
  • Quantitative reverse transcription PCR (RT-qPCR) was used to validate the expression levels of selected DEMs.

    • Main Results:

    • 35 DEMs were identified between DLBCL and control groups.
    • RT-qPCR confirmed significant upregulation of 14 DEMs and downregulation of 9 DEMs in DLBCL.
    • Bioinformatic analysis indicated that target genes of these DEMs are primarily enriched in the PI3K-Akt-MAPK signaling pathway.

    Conclusions:

    • miRNA expression signatures represent potential diagnostic biomarkers for canine DLBCL.
    • The identified miRNA profiles can guide future research into the specific functions and targets of these molecules in DLBCL pathogenesis.
    • This study provides a foundation for developing novel diagnostic and therapeutic strategies for canine DLBCL.