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Ytterbium-DTPA. A potential intravascular contrast agent
Investigative Radiology
|October 1, 1986
Summary
Ytterbium-DTPA shows promise as an intravascular contrast agent, offering greater density than iodine in CT scans and demonstrating good safety in animal studies. Further research is recommended for high kVp imaging techniques.
Area of Science:
- Radiology
- Medical Imaging
- Nuclear Medicine
Background:
- Intravascular contrast agents are crucial for medical imaging.
- Iodine-based agents are widely used but have limitations.
- Novel contrast agents are needed to improve imaging quality and safety.
Purpose of the Study:
- To evaluate Ytterbium-DTPA as a potential intravascular contrast agent.
- To compare the imaging properties of Ytterbium-DTPA with iodine-based agents.
- To assess the toxicity of Ytterbium-DTPA.
Main Methods:
- Synthesis of Ytterbium-DTPA from ytterbium oxide and diethylene triamine penta-acetic acid (DTPA).
- Comparative CT scans of Ytterbium and iodine at varying concentrations and 125 kVp.
- Intravenous administration of Ytterbium-DTPA in rats to determine LD50.
- Enhanced CT scans and pulmonary angiography in dogs to assess contrast enhancement and toxicity.
Main Results:
- Ytterbium demonstrated higher density than iodine at equal concentrations at 125 kVp.
- CT Hounsfield units showed superior enhancement of the aorta and inferior vena cava with Ytterbium-DTPA in dogs.
- The LD50 of intravenous Ytterbium-DTPA in rats was 10 mM/kg.
- No acute or delayed toxicity was observed in animal subjects.
Conclusions:
- Ytterbium-DTPA exhibits superior contrast enhancement compared to iodine.
- Ytterbium-DTPA demonstrates a favorable safety profile in preclinical studies.
- Ytterbium-DTPA warrants further investigation as a contrast agent for high kVp CT imaging.