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Protein ISGylation: a posttranslational modification with implications for malignant neoplasms

Angeles C Tecalco-Cruz1, Jesús Zepeda-Cervantes2

  • 1Postgraduate in Genomic Sciences, Campus Del Valle, Autonomous University of Mexico City (UACM), CDMX 03100, Mexico.

Exploration of Targeted Anti-Tumor Therapy
|September 15, 2023
PubMed

Interferon (IFN)-stimulated gene 15 (ISG15) is a member of the ubiquitin-like (UBL) protein family that can modify specific proteins via a catalytic process called ISGylation. This posttranslational modification can modulate the stability of the ISGylated proteins and protein-protein interactions. Some proteins modified by ISG15 have been identified in malignant neoplasms, suggesting the functional relevance of ISGylation in cancer. This review discusses the ISGylated proteins reported in malignant neoplasms that suggest the potential of ISG15 as a biomarker and therapeutic target in cancer.

Keywords:
ISGylationInterferon-stimulated gene 15cancer

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