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Protein ISGylation: a posttranslational modification with implications for malignant neoplasms
Angeles C Tecalco-Cruz1, Jesús Zepeda-Cervantes2
1Postgraduate in Genomic Sciences, Campus Del Valle, Autonomous University of Mexico City (UACM), CDMX 03100, Mexico.
Interferon-stimulated gene 15 (ISG15) modifies proteins in cancer, impacting stability and interactions. ISG15 shows potential as a cancer biomarker and therapeutic target.
Area of Science:
- Biochemistry
- Molecular Biology
- Oncology
Background:
- Interferon-stimulated gene 15 (ISG15) is a ubiquitin-like protein.
- ISG15 conjugation, termed ISGylation, is a posttranslational modification.
- ISGylation affects protein stability and interactions.
Purpose of the Study:
- To review ISGylated proteins identified in malignant neoplasms.
- To explore the role of ISG15 in cancer.
- To assess ISG15 as a potential cancer biomarker and therapeutic target.
Main Methods:
- Literature review of studies reporting ISGylated proteins in cancer.
- Analysis of the functional implications of ISGylation in malignant neoplasms.
Main Results:
- Several ISGylated proteins have been identified in various cancers.
- ISGylation influences protein stability and interactions relevant to cancer progression.
- These findings highlight the functional significance of ISG15 in malignant neoplasms.
Conclusions:
- ISG15 plays a significant role in cancer.
- ISG15 and its modification, ISGylation, represent promising biomarkers for cancer detection.
- ISG15 is a potential therapeutic target for cancer treatment.
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