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Prognostic impact of highly solid component in early-stage solid lung adenocarcinoma
Taketo Kato1, Shingo Iwano2, Yuki Hanamatsu3
1Department of Thoracic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Quantitative Imaging in Medicine and Surgery
|September 15, 2023
Summary
Three-dimensional solid tumor volume measured by CT accurately predicts outcomes in early-stage lung adenocarcinoma. This quantitative method aids in determining prognosis for solid lung tumors, improving patient care.
Area of Science:
- Radiology
- Oncology
- Medical Imaging
Background:
- Solid lung nodules on CT scans indicate a poorer prognosis than subsolid nodules, regardless of size.
- A systematic method for assessing the prognosis of solid lung tumors using CT is currently lacking.
- Early-stage solid lung adenocarcinoma requires precise prognostic indicators for effective treatment planning.
Purpose of the Study:
- To identify prognostic factors for early-stage solid lung adenocarcinoma using three-dimensional CT volumetry.
- To establish a quantitative method for predicting the postoperative outcome of solid lung tumors.
Main Methods:
- Retrospective analysis of 90 patients with pathological stage I solid lung adenocarcinoma who underwent complete resection.
- Preoperative multidetector CT scans were used to measure two-dimensional axial tumor size, three-dimensional tumor volume, and three-dimensional solid tumor volume.
- Radiological measurements were compared with pathological invasive volume (PIV) and correlated with patient recurrence data.
Main Results:
- Three-dimensional tumor volume and three-dimensional solid tumor volume were significantly different between recurrent and non-recurrent patient groups.
- Multivariate analysis revealed that three-dimensional solid tumor volume (HR: 2.440) and EGFR mutation (HR: 4.307) were significantly associated with disease-free survival.
- Three-dimensional solid tumor volume closely correlated with pathological invasive volume (PIV), unlike the overall three-dimensional tumor volume.
Conclusions:
- Measurement of three-dimensional solid tumor volume using CT is a reliable predictor of postoperative outcomes in early-stage solid lung adenocarcinoma.
- This quantitative CT-based measurement correlates with pathological invasive volume, offering a non-invasive method for prognostic assessment.
- The findings support the use of 3D CT volumetry for improved prognostic evaluation and patient management in lung adenocarcinoma.
