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Updated: Sep 27, 2026
Combination Radiotherapy in an Orthotopic Mouse Brain Tumor Model
Published on: March 6, 2012
Radiotherapy and radiosurgery for meningiomas
William C Chen1, Calixto-Hope G Lucas2, Stephen T Magill3
1Department of Radiation Oncology, University of California San Francisco, San Francisco, CA 94143, USA.
Abstract:
Meningiomas comprise a histologically and clinically diverse set of tumors arising from the meningothelial lining of the central nervous system. In the past decade, remarkable progress has been made in deciphering the biology of these common neoplasms. Nevertheless, effective systemic or molecular therapies for meningiomas remain elusive and are active areas of preclinical and clinical investigation. Thus, standard treatment modalities for meningiomas are limited to maximal safe resection, radiotherapy, or radiosurgery. This review examines the history, clinical rationale, and future directions of radiotherapy and radiosurgery as integral and effective treatments for meningiomas.
Insights
Meningiomas are diverse brain tumors. Current treatments focus on surgery and radiation, as effective systemic therapies are still under development.
Area of Science:
- Neuro-oncology
- Neurosurgery
- Radiation Oncology
Background:
- Meningiomas are common central nervous system tumors with diverse histology and clinical behavior.
- Recent advances have improved understanding of meningioma biology.
- Effective systemic or molecular therapies for meningiomas are still lacking.
Purpose of the Study:
- To review the history, clinical rationale, and future directions of radiotherapy and radiosurgery for meningiomas.
Main Methods:
- Literature review of radiotherapy and radiosurgery for meningiomas.
- Analysis of historical data and current clinical practices.
- Discussion of ongoing preclinical and clinical investigations.
Main Results:
- Maximal safe resection, radiotherapy, and radiosurgery remain the standard treatment modalities for meningiomas.
- Radiotherapy and radiosurgery are integral and effective treatment options.
- Ongoing research aims to develop novel systemic and molecular therapies.
Conclusions:
- Radiotherapy and radiosurgery are established and effective treatments for meningiomas.
- Further research is needed to develop targeted therapies.
- A multidisciplinary approach is crucial for optimal meningioma management.
