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Investigation of the relationship between monocyte chemoattractant protein 1 rs1024611 variant and severity of

Fatemeh Azarfar1, Bahareh Abbasi2, Amir Jalali1

  • 1Department of Biology, Faculty of Sciences, Arak University, Arak, Iran.

Cytokine
|September 15, 2023
PubMed

Insights

The Monocyte Chemoattractant Protein 1 (MCP-1) gene polymorphism does not significantly impact Coronavirus disease 2019 (COVID-19) severity. Clinical factors like lower white blood cell counts and elevated liver enzymes are associated with severe COVID-19 outcomes.

Area of Science:

  • Immunogenetics
  • Virology
  • Clinical Medicine

Background:

  • Monocyte Chemoattractant Protein 1 (MCP-1) expression is elevated in various conditions.
  • Genetic variations in MCP-1 may influence Coronavirus disease 2019 (COVID-19) clinical outcomes.
  • Previous studies suggest a potential link between MCP-1 and disease severity.

Purpose of the Study:

  • To investigate the association between the MCP-1 -2518A/G (rs1024611) polymorphism and COVID-19 severity.
  • To identify clinical and hematological parameters correlated with COVID-19 severity.

Main Methods:

  • Genotyping of the MCP-1 rs1024611 (A/G) polymorphism using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP).
  • Analysis of biochemical and hematological profiles from 116 patients with varying COVID-19 severity (outpatient, hospitalized, ICU).

Main Results:

  • No statistically significant relationship was found between the MCP-1 -2518A/G polymorphism and COVID-19 severity.
  • Multivariate analysis indicated that decreased levels of eosinophils, neutrophils, lymphocytes, and monocytes, along with increased levels of SGPT, SGOT, Neutrophil-to-Lymphocyte Ratio (NLR), C-reactive protein (CRP), ferritin, urea, and D-Dimer, were significantly associated with severe COVID-19 (P < 0.05).

Conclusions:

  • The MCP-1 gene polymorphism does not appear to influence the severity of COVID-19.
  • Further large-scale studies are warranted to validate these findings regarding MCP-1 and COVID-19.
Abstract

Keywords:
AllergyCoronavirus disease 2019MCP-1Severe acute respiratory syndrome coronavirus 2

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