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Auditory phonological identification impairment in primary progressive aphasia
Nobuko Kawakami1, Shigenori Kanno1, Shoko Ota1
1Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan.
Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
|September 15, 2023
Summary
Auditory phonological identification impairment in primary progressive aphasia (PPA) is linked to dysfunction in the superior temporal gyrus and auditory cortex. This study investigated these audiological and neuroanatomical connections in PPA patients.
Area of Science:
- Neuroscience
- Audiology
- Neurology
Background:
- Primary progressive aphasia (PPA) is a neurodegenerative disorder affecting language.
- Auditory phonological identification impairment is a less understood deficit in PPA.
- Understanding the audiological and neuroanatomical basis is crucial for diagnosis and treatment.
Purpose of the Study:
- To investigate the audiological characteristics of phonological identification impairment in PPA.
- To identify the neuroanatomical regions associated with this impairment using neuroimaging.
- To correlate auditory function with brain activity in PPA patients.
Main Methods:
- Twenty-seven patients with various PPA subtypes underwent audiological tests, including phonological identification and temporal auditory acuity assessments.
- Neuropsychological, language, and neuroradiological examinations were performed.
- Regional cerebral blood flow was evaluated using 123I-iodoamphetamine single-photon emission computed tomography.
Main Results:
- Eight patients showed impaired phonological identification, with four having significant deficits.
- Phonological identification ability correlated positively with regional cerebral blood flow in the bilateral superior temporal gyrus and primary auditory cortex.
- Discrepancy scores showed limited correlation with other tests, except for left ear click counting.
Conclusions:
- Progressive dysfunction in the bilateral superior temporal gyrus and primary auditory cortex contributes to phonological identification impairment in PPA.
- These findings highlight the role of auditory processing deficits in PPA.
- Further research into the neurodegenerative mechanisms is warranted.
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