Definitions and implications of the pharmacokinetic-pharmacodynamic parameters of antibiotics in pediatric clinical
Robert Cohen1, Manon Tauzin2, Alexis Rybak3
1Université Paris Est, IMRB-GRC GEMINI, Créteil, France; Clinical Research Center (CRC), Centre Hospitalier Intercommunal de Créteil, France; ACTIV, Association Clinique et Thérapeutique Infantile du Val de Marne, Créteil, France; Pediatric Infectious Pathology Group of the French Pediatric Society, Créteil, France.
Abstract:
Knowledge of infectious diseases and their treatments is constantly evolving. New infectious agents are regularly discovered, mainly due to improvement of identification techniques, especially the development of molecular biology and mass spectrometry. While changes in the epidemiology of infectious diseases are not always predictable or readily understood, several factors regularly enter into consideration, such as not only the natural history of diseases, the impact of vaccinations, but also the excessive and irrational use of antibiotics. Antibiotic resistance is now recognized as one of the major challenges for humanity, especially since few new molecules have been put on the market in recent years. These molecules are reserved for serious infections caused by bacteria resistant to other antibiotics and should only be prescribed by infectious diseases specialists trained in their use. Rationalization of antibiotic therapy is therefore one of the keys to reducing antibiotic resistance and the spread of resistant bacteria. In this guide, for each clinical situation, the bacterial target(s) of antibiotic treatment, the preferred antibiotic choice, and the therapeutic alternatives will be specified. Comments on the diagnosis and treatment of the infection will be added if necessary.
Insights
Antibiotic resistance is a major global challenge due to evolving infectious diseases and irrational antibiotic use. This guide rationalizes antibiotic therapy to combat resistance and guides treatment choices for various infections.
Area of Science:
- Infectious Diseases
- Microbiology
- Pharmacology
Background:
- Infectious disease knowledge is rapidly evolving with new agent discoveries.
- Antibiotic resistance is a significant global health challenge.
- Limited new antibiotic development exacerbates resistance issues.
Purpose of the Study:
- To provide a guide for rationalizing antibiotic therapy.
- To address the challenge of increasing antibiotic resistance.
- To specify bacterial targets, preferred antibiotics, and alternatives for infections.
Main Methods:
- Review of current infectious disease epidemiology.
- Analysis of factors influencing disease patterns, including antibiotic use.
- Compilation of evidence-based treatment recommendations.
Main Results:
- Identification of key bacterial targets for antibiotic treatment.
- Specification of preferred antibiotic choices and therapeutic alternatives.
- Inclusion of diagnostic and treatment considerations for infections.
Conclusions:
- Rational antibiotic therapy is crucial for reducing resistance.
- Specialized knowledge is required for prescribing new antibiotic molecules.
- This guide aims to support evidence-based infectious disease management.
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