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3D printed PLGA implants: How the filling density affects drug release.

C Bassand1, F Siepmann1, L Benabed1

  • 1Univ. Lille, Inserm, CHU Lille, U1008, F-59000 Lille, France.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|September 15, 2023
PubMed
Summary
This summary is machine-generated.

3D printed poly (D,L lactic-co-glycolic acid) implants loaded with ibuprofen showed similar drug release at low densities. High densities resulted in slower release, influenced by swelling and diffusion pathways.

Keywords:
3D printingDrug release mechanismIbuprofenImplantPLGASwelling

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • 3D Printing Technology

Background:

  • Poly (D,L lactic-co-glycolic acid) (PLGA) is a widely used biodegradable polymer for drug delivery.
  • 3D printing offers precise control over the architecture of drug delivery devices.
  • Understanding drug release kinetics from 3D printed implants is crucial for optimizing therapeutic outcomes.

Purpose of the Study:

  • To investigate the effect of filling density on ibuprofen release from 3D printed PLGA implants.
  • To elucidate the mechanisms controlling drug release based on implant architecture and release environment.
  • To provide insights for designing advanced 3D printed drug delivery systems.

Main Methods:

  • Fabrication of mesh-shaped PLGA implants with varying theoretical filling densities (10-100%) using 3D printing (Droplet Deposition Modeling).
  • Quantification of ibuprofen release in phosphate buffer (pH 7.4) and agarose gels.
  • Characterization of implant properties and changes using gravimetric analysis, microscopy, DSC, GPC, and SEM.

Main Results:

  • Drug release was comparable for implants with 10% and 30% filling densities.
  • Implants with 100% filling density exhibited slower release kinetics and altered release profiles in agarose gels.
  • Release behavior was attributed to the presence/absence of a continuous aqueous phase and system swelling, affecting drug diffusion pathways.

Conclusions:

  • Filling density significantly impacts drug release from 3D printed PLGA implants.
  • System swelling and the resulting diffusion path length are key factors controlling drug release.
  • Agarose gel, mimicking tissue, restricts swelling and delays rapid drug release, highlighting the importance of the release environment.