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Updated: Jul 16, 2025

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
Successful management of in-transit cutaneous squamous cell carcinoma with anti-PD-1 immunotherapy
Chris Furkert1, Richard Martin2, Avinash Sharma2
1North Shore Hospital, Auckland, New Zealand. christopher.furkert@waitematadhb.govt.nz.
Abstract:
This report describes the case of a 70-year-old man with metastatic squamous cell carcinoma (SCC) of the right lower leg. Soon after definitive surgical management of the primary and nodal metastases with curative intent, he relapsed, developing aggressive in-transit metastatic disease and recurrent nodal disease. The patient was treated with systemic immunotherapy alone, which not only prompted the progressive nodal metastases to regress, but also resulted in a complete response of the in-transit disease. This situation is previously undescribed in the medical literature.
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