¹⁹ F VT NMR: Novel Tm³⁺ and Ce³⁺ Complexes Provide New Insight into Temperature Measurement Using Molecular Sensors

Area of Science:

• Chemistry
• Physical Chemistry
• Magnetic Resonance Imaging

Background:

• Fluorine-19 (19F) labeled molecules offer unique properties for sensing applications.
• Magnetic resonance (MR) techniques are valuable for probing molecular environments.
• Solvent effects play a crucial role in molecular behavior and sensor response.

Purpose of the Study:

• To investigate the utility of 19F labeled molecules as temperature MR-sensors.
• To determine the influence of different solvents on the chemical shift of 19F labeled molecules.
• To understand the solvent-dependent directionality of chemical shift changes.

Main Methods:

• Nuclear Magnetic Resonance (NMR) spectroscopy was employed to study 19F labeled molecules.
• Chemical shift analysis was performed in various solvent systems.
• Temperature-dependent measurements were conducted to assess sensor capabilities.

Main Results:

• The 19F labeled molecules demonstrated sensitivity to temperature changes, functioning as MR-sensors.
• A significant solvent dependency was observed in the direction of the chemical shift change.
• The magnitude and direction of the 19F chemical shift are modulated by the surrounding solvent environment.

Conclusions:

• 19F labeled molecules are effective temperature MR-sensors.
• Solvent choice critically influences the performance and readout of these sensors.
• Understanding solvent-specific responses is essential for designing targeted MR-sensing applications.