Nuclear factor kappa B expression in non-small cell lung cancer

Area of Science:

• Molecular Biology
• Oncology
• Biochemistry

Background:

• Nuclear factor-kappa B (NF-κB) is a proinflammatory transcription factor regulating genes in inflammation, proliferation, and apoptosis.
• NF-κB dysregulation is implicated in various human cancers, including non-small cell lung cancer (NSCLC).
• Post-translational S-glutathionylation reversibly modifies NF-κB activity via disulfide bond formation with glutathione (GSH).

Conclusions:

• NF-κB plays a significant role in NSCLC progression and is associated with unfavorable prognosis.
• S-glutathionylation is a critical regulatory mechanism for NF-κB.
• Understanding NF-κB regulation by S-glutathionylation may offer therapeutic strategies for NSCLC.