Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Life Histories01:29

Life Histories

18.0K
Overview
18.0K
Hardy-Weinberg Principle01:49

Hardy-Weinberg Principle

72.3K
Diploid organisms have two alleles of each gene, one from each parent, in their somatic cells. Therefore, each individual contributes two alleles to the gene pool of the population. The gene pool of a population is the sum of every allele of all genes within that population and has some degree of variation. Genetic variation is typically expressed as a relative frequency, which is the percentage of the total population that has a given allele, genotype or phenotype.
72.3K
Replicative Cell Senescence02:15

Replicative Cell Senescence

3.7K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
3.7K
Mechanistic Models: Compartment Models in Individual and Population Analysis01:23

Mechanistic Models: Compartment Models in Individual and Population Analysis

64
Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least...
64
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving01:29

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

79
Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
79
Restarting Stalled Replication Forks02:37

Restarting Stalled Replication Forks

5.8K
DNA replication is initiated at sites containing predefined DNA sequences known as origins of replication. DNA is unwound at these sites by the minichromosome maintenance (MCM) helicase and other factors such as Cdc45 and the associated GINS complex.The unwound single strands are protected by replication protein A (RPA) until DNA polymerase starts synthesizing DNA at the 5’ end of the strand in the same direction as the replication fork. To prevent the replication fork from falling apart,...
5.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of esketamine exposure with secondary sclerosing cholangitis in critically ill patients: a retrospective cohort analysis of 20,000 ICU cases.

Journal of intensive care·2026
Same author

Effects of heatwaves on emergency medical service activity in Vienna: a 4-year analysis.

Scientific reports·2026
Same author

Reasons behind individuals' self-ratings of health: an analysis of responses to an open-ended survey question.

BMC public health·2026
Same author

Long-distance genetic relatedness in megalithic central Europe.

Science (New York, N.Y.)·2026
Same author

Impact of high-altitude exposure on Torque Teno virus and immunosuppression levels in lung transplantation recipients: climbing Mount Jebel Toubkal.

Scientific reports·2026
Same author

Halibee member archaeology: Middle Stone Age environment, technology, and postmortem modifications.

Proceedings of the National Academy of Sciences of the United States of America·2026

Related Experiment Video

Updated: Jul 16, 2025

The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan
11:58

The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan

Published on: June 29, 2018

9.5K

Age structure, replicator equation, and the prisoner's dilemma.

Sona John1, Johannes Müller2

  • 1School of Computation, Information and Technology, Department of Mathematics, Technical University of Munich, 85748 Garching, Germany; Comprehensive Pneumology Center (CPC)/Institute of Lung Health and Immunity (LHI), Helmholtz Center Munich, 81377 Munich, Germany.

Mathematical Biosciences
|September 16, 2023
PubMed
Summary

Age structure in populations influences weak frequency-dependent selection in novel ways. This study reveals how life-history traits and time scales simplify complex evolutionary models, promoting cooperation in the prisoner's dilemma.

Keywords:
Age structureCooperationPrisoner’s dilemmaReplicator equation

More Related Videos

Daily Transfers, Archiving Populations, and Measuring Fitness in the Long-Term Evolution Experiment with Escherichia coli
15:00

Daily Transfers, Archiving Populations, and Measuring Fitness in the Long-Term Evolution Experiment with Escherichia coli

Published on: August 18, 2023

3.4K
Measuring Replicative Life Span in the Budding Yeast
12:41

Measuring Replicative Life Span in the Budding Yeast

Published on: June 25, 2009

20.7K

Related Experiment Videos

Last Updated: Jul 16, 2025

The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan
11:58

The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan

Published on: June 29, 2018

9.5K
Daily Transfers, Archiving Populations, and Measuring Fitness in the Long-Term Evolution Experiment with Escherichia coli
15:00

Daily Transfers, Archiving Populations, and Measuring Fitness in the Long-Term Evolution Experiment with Escherichia coli

Published on: August 18, 2023

3.4K
Measuring Replicative Life Span in the Budding Yeast
12:41

Measuring Replicative Life Span in the Budding Yeast

Published on: June 25, 2009

20.7K

Area of Science:

  • Evolutionary Biology
  • Population Dynamics
  • Game Theory

Background:

  • Understanding evolutionary dynamics requires accounting for factors like age structure and selection pressures.
  • Frequency-dependent selection, where fitness depends on trait frequency, is a key evolutionary mechanism.
  • Life-history traits significantly impact population dynamics and evolutionary trajectories.

Purpose of the Study:

  • To investigate the evolutionary dynamics of age-structured populations under weak frequency-dependent selection.
  • To explore the non-trivial influence of life-history traits on evolutionary dynamics.
  • To identify conditions under which age structure promotes cooperation, specifically in the context of the prisoner's dilemma.

Main Methods:

  • Analysis of evolutionary dynamics in age-structured populations.
  • Disentangling population dynamics based on different time scales.
  • Reduction of an infinite-dimensional model to a one-dimensional modified replicator equation using adaptive dynamics.

Main Results:

  • Weak frequency-dependent selection is significantly affected by life-history traits.
  • Identified universal time scales in the interplay of weak selection and life-history traits.
  • The modified replicator equation successfully models cooperation in the prisoner's dilemma.

Conclusions:

  • Age structure plays a crucial role in shaping evolutionary dynamics and promoting cooperation.
  • The identified time scales provide a simplified framework for understanding complex evolutionary processes.
  • Findings offer insights into the evolution of social behaviors in structured populations.