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Updated: Jul 16, 2025

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence
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Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence

Published on: January 7, 2019

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Dissecting multifunctional roles of forkhead box transcription factor D1 in cancers

Lin Cheng1, Haixu Yan2, Yang Liu1

  • 1Department of Neurosurgery, The First Hospital of China Medical University, Shenyang, China.

Biochimica Et Biophysica Acta. Reviews on Cancer
|September 16, 2023
PubMed

Insights

FOXD1, a forkhead box transcription factor, plays a key role in human cancers. This review summarizes FOXD1

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • The forkhead box (FOX) family of transcription factors (TF) includes FOXD1, increasingly recognized for its role in human cancers.
  • Dysregulated FOXD1 signaling is a significant factor in cancer development and progression.
  • A systematic review is needed to consolidate current knowledge on FOXD1 in cancer biology.

Purpose of the Study:

  • To systematically review the functions of FOXD1 in cancer biology.
  • To summarize downstream targets, upstream regulatory mechanisms, and signaling pathways of FOXD1 in cancer.
  • To identify future research directions and potential therapeutic strategies targeting FOXD1's oncogenic activity.

Main Methods:

  • Literature review of current reports on FOXD1 in cancer biology.
  • Analysis of downstream targets and upstream regulatory mechanisms.
  • Examination of related signaling pathways.

Main Results:

  • FOXD1 is a multifunctional transcription factor with significant roles in various human cancers.
  • Detailed understanding of FOXD1's downstream targets and regulatory pathways is presented.
  • Evidence highlights FOXD1's oncogenic activity and its implications in cancer progression.

Conclusions:

  • FOXD1 is a critical regulator in human cancers, involved in development and progression.
  • This review consolidates current knowledge, providing a foundation for future research.
  • Targeting FOXD1 presents potential therapeutic strategies for cancer treatment.
Keywords:
CancerFOXD1Signaling pathwayTargeted therapyTranscription factor

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