Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.7K
Introduction to Membrane Traffic01:44

Introduction to Membrane Traffic

7.2K
The ER, Golgi apparatus, endosomes, and lysosomes work in tandem to modify, sort, and package proteins and lipids. An integrated membrane trafficking network facilitates the back and forth shuttling of molecules within different organelles in the same cell or across the cell membrane.
The transport of soluble and membrane proteins is mediated by transport vesicles that collect cargo from one cellular compartment and deliver it to another by fusing with the target organelle membrane. The Rab...
7.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quadrant-specific assessment of anterior chamber angles in primary angle-closure suspects using anterior segment-OCT: a cross-sectional observational study.

BMC ophthalmology·2026
Same author

Macular microcirculation changes in incident type 2 diabetes without fundus Photography-Detectable diabetic Retinopathy: A 6-Year nested Case-Control study.

Diabetes research and clinical practice·2026
Same author

Harnessing a Functional Rhizobial Partnership with <i>Astragalus sinicus</i> L. to Unlock Phytoremediation Potential for Soil Heavy Metals.

Journal of agricultural and food chemistry·2026
Same author

Undifferentiated pleomorphic sarcoma of the pancreas diagnosed by EUS-guided fine-needle biopsy.

Endoscopic ultrasound·2026
Same author

Comparative Insights into Digestion and Gut Microbiota Modulation of Polysaccharides from Ginseng, Ganoderma lucidum, and Dendrobium officinale.

Foods (Basel, Switzerland)·2026
Same author

Identification of risk factors for postpartum pelvic floor dysfunction in a Chinese population: a retrospective study.

BMC pregnancy and childbirth·2026

Related Experiment Video

Updated: Jul 16, 2025

Scalable Biomanufacturing Workflow to Produce and Isolate Natural Killer Cell-Derived Extracellular Vesicle-Based Cancer Biotherapeutics
08:50

Scalable Biomanufacturing Workflow to Produce and Isolate Natural Killer Cell-Derived Extracellular Vesicle-Based Cancer Biotherapeutics

Published on: August 16, 2024

757

Targeted therapy using engineered extracellular vesicles: principles and strategies for membrane modification.

Qisong Liu1,2, Defeng Li3, Xiaohua Pan4

  • 1National Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, Southern University of Science and Technology, Shenzhen, China.

Journal of Nanobiotechnology
|September 16, 2023
PubMed
Summary

Extracellular vesicles (EVs) are natural nano-carriers with therapeutic potential. Surface modifications enhance their targeting capabilities for improved drug delivery and disease treatment.

Keywords:
ExosomeExtracellular vesiclesSurface modificationTargeted delivery

More Related Videos

Preparation of Plasma Membrane Vesicles from Bone Marrow Mesenchymal Stem Cells for Potential Cytoplasm Replacement Therapy
09:34

Preparation of Plasma Membrane Vesicles from Bone Marrow Mesenchymal Stem Cells for Potential Cytoplasm Replacement Therapy

Published on: May 18, 2017

7.6K
Combined Genetic and Chemical Capsid Modifications of Adenovirus-Based Gene Transfer Vectors for Shielding and Targeting
08:14

Combined Genetic and Chemical Capsid Modifications of Adenovirus-Based Gene Transfer Vectors for Shielding and Targeting

Published on: October 26, 2018

8.5K

Related Experiment Videos

Last Updated: Jul 16, 2025

Scalable Biomanufacturing Workflow to Produce and Isolate Natural Killer Cell-Derived Extracellular Vesicle-Based Cancer Biotherapeutics
08:50

Scalable Biomanufacturing Workflow to Produce and Isolate Natural Killer Cell-Derived Extracellular Vesicle-Based Cancer Biotherapeutics

Published on: August 16, 2024

757
Preparation of Plasma Membrane Vesicles from Bone Marrow Mesenchymal Stem Cells for Potential Cytoplasm Replacement Therapy
09:34

Preparation of Plasma Membrane Vesicles from Bone Marrow Mesenchymal Stem Cells for Potential Cytoplasm Replacement Therapy

Published on: May 18, 2017

7.6K
Combined Genetic and Chemical Capsid Modifications of Adenovirus-Based Gene Transfer Vectors for Shielding and Targeting
08:14

Combined Genetic and Chemical Capsid Modifications of Adenovirus-Based Gene Transfer Vectors for Shielding and Targeting

Published on: October 26, 2018

8.5K

Area of Science:

  • Biotechnology and Nanomedicine
  • Cell Biology and Intercellular Communication

Background:

  • Extracellular vesicles (EVs) are nanoscale vesicles secreted by cells, mediating intercellular communication via cargo delivery.
  • EVs exhibit favorable properties like biocompatibility and low immunogenicity, positioning them as promising therapeutic delivery vehicles.
  • Current limitations in inherent cell-targeting capacity necessitate strategies for enhanced therapeutic efficacy.

Purpose of the Study:

  • To review the biogenesis, composition, uptake, and function of EVs.
  • To explore various cargo loading approaches for EVs.
  • To summarize recent advances in EV surface engineering for targeted therapy applications.

Main Methods:

  • Review of literature on EV biogenesis, cargo loading, and surface modification techniques.
  • Analysis of recent studies on engineered EVs for targeted therapeutic delivery.
  • Focus on strategies for enhancing EV targeting specificity and efficiency.

Main Results:

  • EVs are versatile natural nano-carriers with significant potential in drug delivery.
  • Surface engineering significantly enhances the targeting ability of EVs.
  • Engineered EVs demonstrate promising therapeutic effects across various diseases.

Conclusions:

  • Extracellular vesicles hold substantial promise for targeted delivery of therapeutic cargos.
  • Surface modifications are crucial for optimizing EV targeting and therapeutic outcomes.
  • Targeted EV modifications show efficacy in treating multiple diseases.