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Updated: Jul 16, 2025
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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
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Migraine in older adults.
Sarah Sonja Hugger1, Thien Phu Do2, Håkan Ashina3
1Department of Neurology, Danish Headache Center, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
The Lancet. Neurology
|September 17, 2023
Summary
Migraine presentation and treatment in older adults are complex due to comorbidities and atypical symptoms. More research is needed on migraine remission and effective therapies for this growing population.
Area of Science:
- Neurology
- Gerontology
- Clinical Pharmacology
Background:
- Migraine is a lifelong neurological disorder with varying prevalence across age groups.
- Episodic migraine often remits with age, while chronic migraine may persist into later life.
- Older adults (≥60 years) present unique challenges in migraine diagnosis and treatment due to comorbidities and atypical features.
Purpose of the Study:
- To characterize the changing clinical presentation of migraine across the lifespan.
- To explore the neurobiological basis of migraine remission in older adults.
- To address the unmet clinical needs and evidence gaps for migraine management in the elderly population.
Main Methods:
- Review of existing literature on migraine in older adults.
- Analysis of epidemiological data on migraine prevalence and remission.
- Discussion of neurobiological hypotheses for migraine remission.
- Evaluation of current therapeutic options and their limitations in elderly patients.
Main Results:
- Migraine presentation evolves with age, complicating diagnosis in older adults.
- Comorbidities in older adults can restrict treatment choices for migraine.
- The neurobiological mechanisms underlying migraine remission in aging individuals are not well understood.
- Limited data exists on the effectiveness, tolerability, and safety of novel migraine medications in older populations.
Conclusions:
- Older adults with migraine face specific challenges, including atypical symptoms and limited treatment options.
- There is a critical need for longitudinal studies and targeted research to understand migraine remission and develop effective therapies for the aging population.
- Current evidence for novel migraine treatments in older adults is often lacking due to their exclusion from clinical trials.
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