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Perceived Level of Life Enjoyment and Risk of Developing Disabling Dementia: The Japan Public Health Center-Based
Tomokazu Tajima1, Ai Ikeda1,2, Takeshi Tanigawa1
1Department of Public Health, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Summary
Enjoying life may reduce dementia risk. Higher life enjoyment was linked to a lower incidence of disabling dementia, especially when mental stress was low to moderate.
Area of Science:
- Gerontology
- Public Health
- Neuroscience
Background:
- Life enjoyment, the capacity for pleasure, is a potential factor influencing dementia risk.
- Previous research suggests a link between psychological well-being and cognitive health outcomes.
Purpose of the Study:
- To investigate the association between life enjoyment levels and the incidence of disabling dementia.
- To explore how mental stress modifies this relationship in a Japanese community-dwelling population.
Main Methods:
- A prospective cohort study involving 38,660 Japanese participants aged 45-74.
- Data collected via self-administered questionnaires on psychological conditions and confounders.
- Dementia incidence identified through Japan's Long-Term Care Insurance system (2006-2016), analyzed with Cox models.
Main Results:
- Over 9.4 years, 4,642 cases of disabling dementia occurred.
- Higher life enjoyment significantly reduced disabling dementia risk (HR 0.75 for medium, 0.68 for high enjoyment).
- This protective association was strongest with low-medium mental stress and notable for poststroke dementia in high-stress individuals.
Conclusions:
- Increased life enjoyment is associated with a reduced risk of disabling dementia.
- Managing mental stress is crucial for leveraging life enjoyment to mitigate dementia risk.
- Findings highlight the importance of psychological well-being in dementia prevention strategies.
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