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A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
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Factors Associated With Disease-Modifying Therapy Adherence and Persistence in Multiple Sclerosis: A Scoping
Aliza Bitton Ben-Zacharia1,2, Bryan Walker3, Amy Perrin Ross4
1From Bellevue School of Nursing, Hunter College, New York, NY, USA (AB-Z).
International Journal of MS Care
|September 18, 2023
Summary
Improving multiple sclerosis (MS) disease-modifying therapy (DMT) adherence and persistence is crucial. Older age and prior DMT use positively impact adherence, while factors like alcohol consumption and adverse events negatively affect it.
Area of Science:
- Neurology
- Pharmacology
- Public Health
Background:
- Multiple sclerosis (MS) patients exhibit wide-ranging adherence (27.0–93.8%) and persistence (49.7–96.5%) with disease-modifying therapies (DMTs).
- Optimizing MS care necessitates improved DMT adherence and persistence.
- Understanding associated factors can enhance MS disease management and reveal research gaps.
Purpose of the Study:
- To conduct a scoping literature review on factors influencing DMT adherence and persistence in MS patients.
- To analyze the nature and findings of existing literature on this topic.
Main Methods:
- Included quantitative clinical studies in English focusing on adherence or persistence as primary outcomes.
- Articles were analyzed for factors associated with adherence/persistence, categorized by DMT type: self-injectable, oral, and infusion.
- Fifty-eight studies involving 103,450 patients were reviewed.
Main Results:
- Most studies focused on self-injectable DMTs (n=41).
- Older age and prior DMT use correlated with increased adherence/persistence.
- Negative associations with adherence/persistence included alcohol consumption, DMT adverse events, higher education, and higher BMI.
- Relapse frequency/severity increased adherence but decreased persistence.
Conclusions:
- Further investigation of adherence/persistence factors is needed for oral and infusion DMTs.
- Identifying modifiable factors can guide treatment decisions.
- Improved adherence and persistence can lead to better clinical outcomes in MS patients.
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