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Related Experiment Videos

Calcium stimulates vasopressin release.

I Gavras, S Hatinoglou, A Benetos

    Journal of Hypertension
    |August 1, 1986
    PubMed
    Summary

    Acute hypercalcemia increases blood pressure by elevating arginine vasopressin (AVP) levels. This study demonstrates AVP

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    Area of Science:

    • Nephrology
    • Endocrinology
    • Cardiovascular Physiology

    Background:

    • The link between acute hypercalcemia and hypertension is established but mechanistically unclear.
    • Previous research has not identified significant roles for the renin-angiotensin or sympathetic nervous systems in this pressor response.
    • The potential involvement of arginine vasopressin (AVP) in calcium-induced hypertension requires investigation.

    Purpose of the Study:

    • To investigate the role of arginine vasopressin (AVP) in mediating hypertension associated with acute hypercalcemia.
    • To determine if AVP inhibition can reverse calcium-induced blood pressure elevation.

    Main Methods:

    • Infusion of calcium gluconate or calcium chloride in anephric and intact rats.
    • Measurement of mean blood pressure and plasma AVP levels.
    • Administration of a specific vasopressin V1 inhibitor to assess its effect on blood pressure.

    Main Results:

    • Calcium infusion significantly increased blood pressure and plasma AVP levels in anephric rats.
    • AVP inhibition effectively lowered blood pressure in calcium-infused anephric rats.
    • Calcium chloride infusion mimicked the effects of calcium gluconate, confirming the calcium ion's role.
    • Indomethacin treatment attenuated the pressor response to calcium and prevented AVP elevation.

    Conclusions:

    • Acute hypercalcemia induces hypertension, at least in part, through a mechanism involving arginine vasopressin (AVP).
    • The calcium ion directly stimulates AVP release, leading to increased blood pressure.
    • Prostaglandin synthesis may play a role in mediating the pressor effects of calcium and AVP release.

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