Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Clinically Relevant Drug Product Specifications: Methods of Establishment

Clinically Relevant Drug Product Specifications: Methods of Establishment

Product specifications define the acceptable quality of a pharmaceutical product by ensuring identity, purity, potency, and strength. These specifications serve as benchmarks during development, manufacturing, and post-approval quality control. Clinically relevant specifications are particularly important because they directly relate to a drug's safety and efficacy in clinical use.Dissolution studies are critical biopharmaceutic tools that link in vitro behavior to in vivo performance. They...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Regioselective Synthesis of Methyl Enol Ethers from Cycloalkanones via O-Methylation of Kinetic Enolates.

Synthesis·2026

Same author

Recent Contributions of Organic Synthesis to Forensic Science.

ChemPlusChem·2026

Same author

Hit-Identification to Novel Antileishmanial Agents from a β‑Pinene Scaffold: from Synthesis to <i>In Vitro</i> Evaluation and <i>In Silico</i> SAR/ADMET Profiling.

ACS omega·2026

Same author

Recent Advances in Bioconjugation of Aromatic Amino Acid Residues by a Reactivity-Guided Approach.

Chemical record (New York, N.Y.)·2025

Same author

Direct Synthesis of α‑Amino Ketones via Photochemical Nickel-Catalyzed Acyl-Aryl Cross-Coupling.

ACS omega·2025

Same author

High-Accuracy Quantitative Nuclear Magnetic Resonance Using Improved Solvent Suppression Schemes.

Analytical chemistry·2025

Search research articles

Related Experiment Video

Updated: Jul 6, 2026

Color Spot Test As a Presumptive Tool for the Rapid Detection of Synthetic Cathinones

Color Spot Test As a Presumptive Tool for the Rapid Detection of Synthetic Cathinones

Published on: February 5, 2018

Developing Amphetamine Certified Reference Materials: From Batch and Continuous-Flow Synthesis to Certification

Thais G Silva¹, Rodrigo O M A de Souza², Bruno C Garrido³

¹Laboratório de Síntese Orgânica, Instituto de Pesquisas de Produtos Naturais, Universidade Federal do Rio de Janeiro, 21941-599, Rio de Janeiro, Brasil.

|September 18, 2023

Summary

This summary is machine-generated.

This study developed a fast and efficient synthesis for certified reference materials (CRM) of amphetamine derivatives like MDA and MDMA. The new method ensures high purity and supports forensic chemistry and potential therapeutic applications.

Keywords:

Wacker-Tsuji oxidation amphetamines certified reference material flow chemistry reductive amination

More Related Videos

Technical Aspect of the Automated Synthesis and Real-Time Kinetic Evaluation of [11C]SNAP-7941

Technical Aspect of the Automated Synthesis and Real-Time Kinetic Evaluation of [11C]SNAP-7941

Published on: April 28, 2019

Detection of Regulated Ergot Alkaloids in Food Matrices by Liquid Chromatography-Trapped Ion Mobility Spectrometry-Time-of-Flight Mass Spectrometry

Detection of Regulated Ergot Alkaloids in Food Matrices by Liquid Chromatography-Trapped Ion Mobility Spectrometry-Time-of-Flight Mass Spectrometry

Published on: November 22, 2024

Related Experiment Videos

Last Updated: Jul 6, 2026

Color Spot Test As a Presumptive Tool for the Rapid Detection of Synthetic Cathinones

Color Spot Test As a Presumptive Tool for the Rapid Detection of Synthetic Cathinones

Published on: February 5, 2018

Technical Aspect of the Automated Synthesis and Real-Time Kinetic Evaluation of [11C]SNAP-7941

Technical Aspect of the Automated Synthesis and Real-Time Kinetic Evaluation of [11C]SNAP-7941

Published on: April 28, 2019

Detection of Regulated Ergot Alkaloids in Food Matrices by Liquid Chromatography-Trapped Ion Mobility Spectrometry-Time-of-Flight Mass Spectrometry

Detection of Regulated Ergot Alkaloids in Food Matrices by Liquid Chromatography-Trapped Ion Mobility Spectrometry-Time-of-Flight Mass Spectrometry

Published on: November 22, 2024

Area of Science:

Forensic Chemistry
Synthetic Chemistry
Analytical Chemistry

Background:

Certified reference materials (CRMs) are crucial for accurate forensic analysis and drug testing.
Existing synthesis methods for amphetamine derivatives may lack efficiency or scalability.
There is a growing demand for reliable calibrants in forensic science and pharmaceutical research.

Purpose of the Study:

To develop a rapid, efficient, and scalable synthesis for amphetamine derivative CRMs.
To establish a comprehensive certification protocol for these CRMs.
To produce high-purity CRMs for forensic and potential therapeutic applications.

Main Methods:

Two-step synthesis of MDA, MDMA, PMA, and PMMA from safrole and estragole.
Optimization of synthesis under both batch and continuous-flow conditions.
Development of a certification protocol including identity, homogeneity, stability, and characterization studies.

Main Results:

Achieved overall yields of 38-61% in 48 hours (batch) and 61-65% in 65 minutes (continuous-flow).
Successfully produced a highly pure CRM of MDA.HCl with a certified value of 99.1±1.4 g/100 g.
Established a robust certification protocol for amphetamine derivative CRMs.

Conclusions:

The developed synthesis offers a pioneering and efficient approach for producing amphetamine derivative CRMs.
The high-purity CRMs are vital for forensic chemistry, public security, and potential therapeutic research.
Continuous-flow synthesis presents a significant advantage in terms of speed and yield for CRM production.