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A novel function of CREG in metabolic disorders
Yang Li1, Xiaoxiang Tian1, Quanyu Zhang1
1Cardiovascular Research Institute and Department of Cardiology, General Hospital of Northern Theater Command, Shenyang 110016, Liaoning, China.
Medical Review (2021)
|September 19, 2023
Summary
Cellular repressor of E1A-stimulated genes (CREG) is crucial for maintaining cell homeostasis and is increasingly linked to metabolic disorders. This review explores CREG
Area of Science:
- Biochemistry and Molecular Biology
- Metabolic Research
- Cellular Biology
Background:
- Metabolic disorders represent a significant global health challenge, necessitating novel therapeutic interventions.
- Cellular repressor of E1A-stimulated genes (CREG) is widely expressed in mammalian tissues and vital for cellular and tissue homeostasis.
- Emerging evidence highlights CREG's significant role as a mediator in the pathogenesis of metabolic disorders.
Purpose of the Study:
- To review the structure and molecular regulation of CREG.
- To discuss CREG's involvement in metabolic disorders.
- To explore therapeutic strategies targeting CREG for metabolic disorder treatment.
Main Methods:
- Literature review of studies on CREG structure and function.
- Analysis of research linking CREG to metabolic disease pathways.
- Synthesis of current therapeutic approaches targeting CREG.
Main Results:
- CREG's structure and complex molecular regulatory mechanisms are detailed.
- CREG's critical role in the development and progression of various metabolic disorders is established.
- Potential therapeutic strategies involving CREG modulation are identified.
Conclusions:
- CREG is a key player in maintaining metabolic homeostasis.
- Targeting CREG presents a promising avenue for developing new treatments for metabolic disorders.
- Further research into CREG regulation and therapeutic applications is warranted.
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