Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

4.1K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.1K
Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

34.7K
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
34.7K
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

87
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
87
Management of Insomnia01:19

Management of Insomnia

278
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
278
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

1.4K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
1.4K
Understanding Sleep01:11

Understanding Sleep

297
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
297

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Histone deacetylase enzyme activity is not the universal anticancer target of HDAC inhibitors.

Signal transduction and targeted therapy·2026
Same author

Cardiac HDAC3 Disruption Contributes to HDAC Inhibitor-Induced QT Prolongation.

Cells·2026
Same author

Epigenetically regulated pancreatic GABA-somatostatin signaling underlies gestational diabetes-induced glucose intolerance in offspring.

Science translational medicine·2026
Same author

YAP-Induced Glycolysis Drives Fibroinflammation and Disrupts Fibroblast Fidelity.

Circulation research·2025
Same author

Muscle Rev-erb controls time-dependent adaptations to chronic exercise in mice.

Nature communications·2025
Same author

A myofiber-derived secreted factor for muscle regeneration.

Life metabolism·2025
Same journal

Proactive personalized early warning systems: the next frontier in climate-health preparedness.

Medical review (2021)·2026
Same journal

Severe trauma care: advances and future directions in diagnostic and therapeutic techniques and information technology support.

Medical review (2021)·2026
Same journal

Mother-to-offspring microbial vertical transmission: timing, determinants, and impact on offspring susceptibility to gastrointestinal diseases.

Medical review (2021)·2026
Same journal

Endogenous jaw bone regeneration: past, present, and future.

Medical review (2021)·2026
Same journal

Current status, development and challenges in the treatment of chronic graft-versus-host disease.

Medical review (2021)·2026
Same journal

Decoding DNA metabolism and its clinical relevance through the lens of high-throughput sequencing assays.

Medical review (2021)·2026
See all related articles

Related Experiment Video

Updated: Jul 16, 2025

Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System
07:34

Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System

Published on: December 16, 2022

2.3K

Circadian clock and temporal meal pattern.

Xin Li1,2, Zheng Sun1,2

  • 1Department of Medicine - Endocrinology, Diabetes, and Metabolism, Baylor College of Medicine, Houston, TX, USA.

Medical Review (2021)
|September 19, 2023
PubMed
Summary
This summary is machine-generated.

Eating breakfast aids weight management and metabolic health, while late meals and irregular eating patterns negatively impact metabolism. Time-restricted feeding (TRF) shows metabolic benefits, potentially independent of the circadian clock.

Keywords:
cardiometaboliccircadian rhythmdaily variationdiabetesmeal responsesuprachiasmatic nuclei

More Related Videos

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

8.4K
Recording and Analysis of Circadian Rhythms in Running-wheel Activity in Rodents
05:46

Recording and Analysis of Circadian Rhythms in Running-wheel Activity in Rodents

Published on: January 24, 2013

21.4K

Related Experiment Videos

Last Updated: Jul 16, 2025

Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System
07:34

Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System

Published on: December 16, 2022

2.3K
Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

8.4K
Recording and Analysis of Circadian Rhythms in Running-wheel Activity in Rodents
05:46

Recording and Analysis of Circadian Rhythms in Running-wheel Activity in Rodents

Published on: January 24, 2013

21.4K

Area of Science:

  • Chronobiology
  • Metabolic Health
  • Nutritional Science

Background:

  • The brain's central circadian clock regulates daily variations in meal responses, influencing glycemic, satiety, and thermogenic effects.
  • Consuming calories, especially carbohydrates, at breakfast is linked to better obesity and metabolic syndrome management compared to dinner.
  • Breakfast skipping and late dinners can lead to adverse metabolic outcomes, while the impact of meal frequency is debated.

Purpose of the Study:

  • To explore the metabolic effects of temporal meal patterns.
  • To understand the role of the circadian clock in metabolic regulation.
  • To investigate the impact of time-restricted feeding (TRF) on metabolism.

Main Methods:

  • Review of studies on circadian rhythms and meal timing.
  • Analysis of research on breakfast consumption, meal frequency, and late-night eating.
  • Examination of findings on time-restricted feeding (TRF) in humans and rodents.

Main Results:

  • Meals consumed upon waking elicit lower glycemic but higher satiety/thermogenic responses.
  • Regular breakfast consumption benefits chronic obesity management; irregular meals, especially breakfasts, have adverse effects.
  • Time-restricted feeding (TRF) improves metabolism and lifespan, with benefits in humans linked to caloric restriction, but potentially independent of the circadian clock in rodents.

Conclusions:

  • Temporal meal patterns significantly influence metabolic health.
  • Understanding neuroendocrine mechanisms of clock-mediated regulation is crucial for deciphering the metabolic impact of meal timing.
  • TRF may offer metabolic benefits, potentially by mitigating circadian disruption, though its mechanisms may differ between species.