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Updated: Aug 8, 2026

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy
Published on: April 13, 2022
Application of Organoids in Regenerative Medicine
Yinghua Wu1,2, Wenrui Ye1,2, Yong Gao3
1Department of Neurosurgery, Xiangya Hospital, Central South University (CSU), Changsha, Hunan, People's Republic of China.
Abstract:
Regenerative medicine mainly relies on heterologous transplantation, often hindered by sample availability and ethical issues. Furthermore, patients are required to take immunosuppressive medications to prevent adverse side effects. Stem cell-derived 3D-organoid culture has provided new alternatives for transplantation and regenerative medicine. Scholars have combined organoids with tissue engineering technology to improve reproducibility, the accuracy of constitution and throughput, and genetic correction to achieve a more personalized therapy. Here, we review the available applications of organoids in regenerative medicine and the current challenges concerning this field.
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