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Fluorescence Assays for the Study of Mycobacterium tuberculosis Interaction with the Immune Receptor SLAMF1
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Fluorescence Assays for the Study of Mycobacterium tuberculosis Interaction with the Immune Receptor SLAMF1

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MDA5 RNA-sensing pathway activation by Mycobacterium tuberculosis promotes innate immune subversion and pathogen

C Korin Bullen, Alok K Singh, Stefanie Krug

    JCI Insight
    |September 19, 2023
    PubMed
    Summary

    The RIG-I-like receptor MDA5 senses Mycobacterium tuberculosis RNA, promoting bacterial growth. Eliminating MDA5 enhances macrophage immune response and host survival against tuberculosis.

    Keywords:
    ImmunologyInfectious diseaseInnate immunityTuberculosis

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