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Related Concept Videos

Colloids03:22

Colloids

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Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles that are visible to the naked eye or can be seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. On the other hand, a solution is a homogeneous mixture in which no settling occurs and in which the dissolved...
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The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...
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Preparation of Cubosomes with Improved Colloidal and Structural Stability Using a Gemini Surfactant.

Masao Nagao1,2, Abdul-Hackam Ranneh3, Yasunori Iwao4

  • 1Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.

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Summary

Gemini surfactant sodium dilauramidoglutamide lysine (DLGL) enhances phytantriol (PHY) cubosome stability for drug delivery systems (DDS). DLGL-stabilized cubosomes show promise for heat-sensitive pharmaceuticals requiring refrigerated storage.

Keywords:
cubosomesdrug delivery systemsgemini surfactantlipid-based liquid crystalline nanoparticlesstability improvement

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Area of Science:

  • Nanotechnology and Materials Science
  • Pharmaceutical Sciences and Drug Delivery

Background:

  • Cubosomes, nanoparticles with bicontinuous cubic structures, are promising for drug delivery systems (DDS).
  • A key limitation for cubosomes in medical applications is their insufficient structural stability.
  • Gemini surfactants, like sodium dilauramidoglutamide lysine (DLGL), offer potential for stabilizing nanostructures.

Purpose of the Study:

  • To investigate the stabilization of phytantriol (PHY)-based cubosomes using the gemini surfactant DLGL.
  • To determine the optimal concentrations and conditions for DLGL-PHY cubosome formation and stability.
  • To evaluate the potential of DLGL-stabilized cubosomes for drug delivery applications, particularly for heat-sensitive materials.

Main Methods:

  • Preparation of cubosome nanosuspensions using specific mixing ratios of DLGL and PHY in water via ultrasonication.
  • Characterization of cubosome structure and morphology using dynamic light scattering (DLS), small-angle X-ray scattering (SAXS), and cryo-transmission electron microscopy (cryo-TEM).
  • Assessment of cubosome stability upon addition of phosphate-buffered saline (PBS) and under different temperature storage conditions (5 °C and 25 °C).

Main Results:

  • Formation of Pn3̅m cubosomes was confirmed at DLGL/PHY solid ratios between 1-3% w/w, with lattice parameters around 7 nm.
  • At higher DLGL/PHY ratios (≥5% w/w), cubosome formation was inhibited, leading to small unilamellar vesicles; however, Im3̅m cubosomes formed at 6-10% w/w.
  • Pn3̅m cubosomes exhibited remarkable stability for 4 weeks at both 5 °C and 25 °C, indicating suitability for refrigerated storage.

Conclusions:

  • Sodium dilauramidoglutamide lysine (DLGL) effectively stabilizes phytantriol (PHY) cubosomes at specific concentrations, acting as a novel stabilizer.
  • DLGL-stabilized cubosomes demonstrate excellent structural integrity under low-temperature storage, crucial for heat-sensitive drug delivery applications.
  • These findings highlight DLGL-based cubosomes as a viable and stable platform for advanced drug delivery systems.