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Related Concept Videos

Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Hematopoiesis01:21

Hematopoiesis

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The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
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Overview of Hematopoiesis01:20

Overview of Hematopoiesis

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Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
4.1K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

3.1K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Lineage Commitment01:21

Lineage Commitment

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Commitment is the  process whereby stem cells:
3.0K
Erythropoiesis01:14

Erythropoiesis

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Red blood cells  (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis is the process of RBC production. In healthy individuals, erythropoiesis ensures all tissues are amply supplied with oxygen. In addition, blood loss due to injury leads to a drop in the physiological oxygen level that will cause erythropoiesis. Any defect in erythropoiesis leads to several physiological disorders, including thalassemia, anemia,...
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Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
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Clonal haematopoiesis - a novel entity that modifies pathological processes in elderly.

Ekaterina Belotserkovskaya1, Vasily Golotin1,2, Burhan Uyanik3

  • 1Institute of Cytology RAS, 4 Tikhoretskii prospect, St. Petersburg, 194064, Russia.

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Summary

New sequencing technologies reveal clonal hematopoiesis, the presence of mutated blood cells in older adults without disease. This review explores its implications for age-related diseases.

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Characterizing Mutational Load and Clonal Composition of Human Blood
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Characterizing Mutational Load and Clonal Composition of Human Blood
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Characterizing Mutational Load and Clonal Composition of Human Blood

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Area of Science:

  • Genomics
  • Hematology
  • Aging Research

Background:

  • Advancements in sequencing technology have increased accessibility and sensitivity.
  • This has enabled the discovery of novel biological phenomena.

Purpose of the Study:

  • To review the recent advancements in understanding clonal hematopoiesis.
  • To explore the potential impact of clonal hematopoiesis on age-related disease development.

Main Methods:

  • Review of current literature on sequencing technologies and clonal hematopoiesis.
  • Analysis of genetic mutations associated with clonal hematopoiesis.
  • Examination of epidemiological data linking clonal hematopoiesis to disease.

Main Results:

  • Clonal hematopoiesis is characterized by minor blood cell clones with gene mutations in the elderly.
  • These mutations occur in specific genes but do not initially cause hematopoietic disease.
  • The phenomenon is increasingly recognized due to improved sequencing capabilities.

Conclusions:

  • Clonal hematopoiesis represents a significant finding in aging and hematology.
  • Further research is needed to elucidate its role in the pathogenesis of age-related diseases.
  • Understanding clonal hematopoiesis may offer new avenues for disease prevention and treatment.