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Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
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Clonal haematopoiesis - a novel entity that modifies pathological processes in elderly

Ekaterina Belotserkovskaya1, Vasily Golotin1,2, Burhan Uyanik3

  • 1Institute of Cytology RAS, 4 Tikhoretskii prospect, St. Petersburg, 194064, Russia.

Cell Death Discovery
|September 19, 2023
PubMed

Progress in the development of new sequencing techniques with wider accessibility and higher sensitivity of the protocol of deciphering genome particularities led to the discovery of a new phenomenon - clonal haematopoiesis. It is characterized by the presence in the bloodstream of elderly people a minor clonal population of cells with mutations in certain genes, but without any sign of disease related to the hematopoietic system. Here we will review this recent advancement in the field of clonal haematopoiesis and how it may affect the disease's development in old age.

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