Selenium in combination with a tomato lipid extract as a therapy for benign prostatic hyperplasia and its alterations
David Julian Arias-Chávez1, Patrick Mailloux-Salinas1, Jessica Ledesma Aparicio1
1Departmento de Farmacobiología, Centro de Investigación y de Estudios Avanzados del IPN, Sede Sur, Mexico City, Mexico.
Abstract:
Benign prostatic hyperplasia (BPH) is the most common adenoma in old men. Tomatoes are a rich source of bioactive compounds that, as well as selenium (Se), possess antioxidant and antiproliferative activity. The aim was to evaluate the therapeutic effect of Se in combination with a tomato extract in aged rats with BPH. Aged male Wistar rats were divided in the following groups (n = 10 rats/group): Control (C), BPH, BPH + Finasteride (BPH + F), BPH + Tomato Lipidic Extract (BPH + E), BPH + Selenium (BPH + S) and BPH plus E plus S (BPH + E + S). After 4 weeks of treatment, prostate weight, diuresis, antioxidants enzymes, prooxidants and inflammatory markers, growth factors and androgens were determined. BPH + E + S reduced prostate weight by 59.29% and inhibited growth by 99.35% compared to BPH + F which only decreased weight and inhibited growth by 15.31% and 57.54%, respectively. Prooxidant markers were higher with BPH + F (49.4% higher vs. BPH), but BPH + E + S decreased these markers (94.27% vs. BPH) and increased antioxidant activity. Finally, diuresis was higher with the BPH + E + S combination and markers of inflammation and growth factors were significantly lower with respect to BPH + F. Our findings provide a beneficial and protective therapeutic option of E + S directed against androgens, oxidative stress and inflammation that regulates cell proliferation in the prostate gland.
Insights
Selenium combined with tomato extract significantly reduced prostate weight and inhibited growth in aged rats with benign prostatic hyperplasia (BPH). This combination therapy offers a potent, protective option against prostate cell proliferation, oxidative stress, and inflammation.
Area of Science:
- Urology
- Nutritional Science
- Oncology
Background:
- Benign prostatic hyperplasia (BPH) is a common condition in aging men.
- Tomatoes contain bioactive compounds with antioxidant and antiproliferative properties.
- Selenium (Se) also exhibits antioxidant and antiproliferative activities.
Purpose of the Study:
- To investigate the therapeutic efficacy of combining selenium (Se) with a tomato lipidic extract (E) in a rat model of BPH.
- To evaluate the effects of this combination on prostate weight, diuresis, oxidative stress, inflammation, and growth factors.
Main Methods:
- Aged male Wistar rats were induced with BPH and treated with Finasteride (F), tomato extract (E), selenium (S), or a combination (E+S).
- Control and BPH groups were included for comparison.
- Prostate weight, diuresis, antioxidant/prooxidant markers, inflammatory markers, growth factors, and androgens were assessed after 4 weeks.
Main Results:
- The BPH+E+S combination significantly reduced prostate weight (59.29%) and inhibited growth (99.35%) compared to BPH+F (15.31% weight reduction, 57.54% growth inhibition).
- BPH+E+S decreased prooxidant markers (94.27% reduction vs. BPH) and increased antioxidant activity, unlike BPH+F which elevated prooxidant markers.
- The BPH+E+S group showed improved diuresis and significantly lower markers of inflammation and growth factors compared to BPH+F.
Conclusions:
- Selenium and tomato extract combination (E+S) is a highly effective therapeutic strategy for BPH in aged rats.
- This combination demonstrates superior efficacy over Finasteride in reducing prostate size and inhibiting proliferation.
- E+S offers a beneficial therapeutic option by targeting androgens, oxidative stress, and inflammation, thereby regulating prostate cell proliferation.
